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CAS 90996-54-6

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Rhizoxin

Description:
Rhizoxin is a natural product derived from the fungus Rhizopus chinensis, known for its potent antitumor properties. It belongs to the class of compounds known as polyketides and exhibits a complex molecular structure that contributes to its biological activity. Rhizoxin functions primarily as a microtubule inhibitor, disrupting the normal function of the mitotic spindle during cell division, which leads to cell cycle arrest and ultimately apoptosis in cancer cells. This mechanism makes it a subject of interest in cancer research and drug development. The compound has shown efficacy against various cancer cell lines in preclinical studies. However, its clinical application is limited due to toxicity and the need for further research to optimize its therapeutic potential. Additionally, Rhizoxin's solubility and stability in biological systems are important factors that influence its pharmacokinetics and bioavailability. Overall, Rhizoxin represents a promising avenue for the development of novel anticancer therapies, although more studies are needed to fully understand its mechanisms and potential applications.
Formula:C35H47NO9
InChI:InChI=1/C35H47NO9/c1-19(13-25-18-41-23(5)36-25)9-8-10-21(3)32(40-7)22(4)27-17-29(37)35(6)30(45-35)12-11-20(2)26-14-24(16-31(38)42-26)15-28-33(43-28)34(39)44-27/h8-13,18,20,22,24,26-30,32-33,37H,14-17H2,1-7H3/b9-8+,12-11+,19-13+,21-10+/t20-,22-,24-,26+,27-,28-,29-,30+,32+,33+,35-/m1/s1
InChI key:InChIKey=OWPCHSCAPHNHAV-QIPOKPRISA-N
SMILES:C[C@@]12[C@](O1)(/C=C/[C@@H](C)[C@]3(C[C@@](C[C@]4([C@](C(=O)O[C@]([C@@H]([C@H](/C(=C/C=C/C(=C/C5=COC(C)=N5)/C)/C)OC)C)(C[C@@H]2O)[H])(O4)[H])[H])(CC(=O)O3)[H])[H])[H]
Synonyms:
  • WF 1360
  • [1S-[1R*,3R*,5S*,8R*(1R*,2S*,3E,5E,7E),10R*,11S*,13S*,14E,16S*,17S*]]-10-Hydroxy-8-[2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione
  • 4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, [1S-[1R*,3R*,5S*,8R*(1R*,2S*,3E,5E,7E),10R*,11S*,13S*,14E,16S*,17S*]]-
  • Rhizoxin
  • 4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicosane, rhizoxin deriv.
  • See more synonyms
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Found 1 products.
  • Rhizoxin
    Targetmol
    + Info

    Rhizoxin

    CAS:
    <p>Rhizoxin: antitumor macrocyclic lactone from Rhizopus chinensis; binds tubulin, blocks microtubule formation.</p>
    Formula:C35H47NO9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:625.75

    Ref: TM-T26076