CAS 91-33-8: Benzthiazide

Description: Benzthiazide is a thiazide diuretic, primarily used in the treatment of hypertension and edema associated with various conditions, such as heart failure. It is characterized by its chemical structure, which includes a benzene ring fused to a thiazide moiety, contributing to its pharmacological properties. The substance is typically a white to off-white crystalline powder that is slightly soluble in water and more soluble in organic solvents. Benzthiazide functions by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, leading to increased excretion of sodium and water, thereby reducing blood volume and blood pressure. Its mechanism of action also involves mild vasodilatory effects. The compound has a relatively low toxicity profile, but like other diuretics, it may cause electrolyte imbalances, particularly hypokalemia. Benzthiazide is often administered orally and may be used in combination with other antihypertensive agents to enhance therapeutic efficacy. As with any medication, monitoring for side effects and interactions is essential during treatment.

Formula: C₁₅H₁₄ClN₃O₄S₃

InChI: InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)

InChI key: InChIKey=NDTSRXAMMQDVSW-UHFFFAOYSA-N

SMILES: O=S1(=O)N=C(NC2=CC(Cl)=C(C=C21)S(=O)(=O)N)CSCC=3C=CC=CC3

Synonyms:

• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-[(benzylthio)methyl]-6-chloro-, 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• 3-[(Benzylthio)methyl]-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 3-[(benzylsulfanyl)methyl]-6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Aquatag
• Benzothiazide
• Benzotiazida
• Benzthazide
• Benzthiazid
• Dihydrex
• Diucen
• Diucene
• Edemex
• ExNa
• Exosalt
• Fovane
• Freeuril
• HyDrine
• Lemazide
• P 1393
• Pfizer 1393
• Proaqua
• Regulon
• Urese

Benzthiazide

CAS: 91-33-8

Benzthiazide treats edema and hypertension by promoting diuresis and inhibiting kidney Na+/Cl- reuptake, but may …

• Formula: C₁₅H₁₄ClN₃O₄S₃
• Purity: 100% - 99.79%
• Color and Shape: Crystals From Acetone Solid
• Molecular weight: 431.94

Benzthiazide

CAS: 91-33-8

• Formula: C₁₅H₁₄ClN₃O₄S₃
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 431.9374

Benzthiazide

CAS: 91-33-8

• Purity: ≥98%
• Molecular weight: 431.94g/mol

Benzthiazide

CAS: 91-33-8

• Formula: C₁₅H₁₄ClN₃O₄S₃
• Color and Shape: Neat
• Molecular weight: 431.94

Benzthiazide

CAS: 91-33-8

Applications Benzthiazide is a diuretic, antihypertensive agent. References Mollica, J., et al.: J. Pharm. Sci., …

• Formula: C₁₅H₁₄ClN₃O₄S₃
• Color and Shape: Neat
• Molecular weight: 431.94

Benzthiazide

CAS: 91-33-8

Benzthiazide is a drug that inhibits the enzyme cyclic nucleotide phosphodiesterase, which regulates the production …

• Formula: C₁₅H₁₄ClN₃O₄S₃
• Purity: Min. 95%
• Molecular weight: 431.94 g/mol