CAS 91-33-8

Benzthiazide

Description:

Benzthiazide is a thiazide diuretic, primarily used in the treatment of hypertension and edema associated with various conditions, such as heart failure. It is characterized by its chemical structure, which includes a benzene ring fused to a thiazide moiety, contributing to its pharmacological properties. The substance is typically a white to off-white crystalline powder that is slightly soluble in water and more soluble in organic solvents. Benzthiazide functions by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, leading to increased excretion of sodium and water, thereby reducing blood volume and blood pressure. Its mechanism of action also involves mild vasodilatory effects. The compound has a relatively low toxicity profile, but like other diuretics, it may cause electrolyte imbalances, particularly hypokalemia. Benzthiazide is often administered orally and may be used in combination with other antihypertensive agents to enhance therapeutic efficacy. As with any medication, monitoring for side effects and interactions is essential during treatment.

Formula: C₁₅H₁₄ClN₃O₄S₃

InChI: InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)

InChI key: InChIKey=NDTSRXAMMQDVSW-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(NC(CSCC3=CC=CC=C3)=N1)=CC(Cl)=C(S(N)(=O)=O)C2

Synonyms:

• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-[(benzylthio)methyl]-6-chloro-, 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
• 3-Benzylthiomethyl-6-chloro-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• 3-[(Benzylthio)methyl]-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 3-[(benzylsulfanyl)methyl]-6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Aquatag
• Benzothiazide
• Benzotiazida
• Benzthazide
• Benzthiazid
• Dihydrex
• Diucen
• Diucene
• Edemex
• ExNa
• Exosalt
• Fovane
• Freeuril
• HyDrine
• Lemazide
• P 1393
• Pfizer 1393
• Proaqua
• Regulon

Benzthiazide

CAS: 91-33-8

Benzthiazide treats edema and hypertension by promoting diuresis and inhibiting kidney Na+/Cl- reuptake, but may reduce potassium and raise uric acid.

Formula: C₁₅H₁₄ClN₃O₄S₃

Purity: 99.34% - 99.79%

Color and Shape: Crystals From Acetone Solid

Molecular weight: 431.94

Ref: TM-T0782

Benzthiazide

CAS: 91-33-8

Formula: C₁₅H₁₄ClN₃O₄S₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 431.9374

Ref: IN-DA0038JK

Benzthiazide

CAS: 91-33-8

Benzthiazide

Purity: ≥98%

Molecular weight: 431.94g/mol

Ref: 54-BUP16551

Benzthiazide

Controlled Product

CAS: 91-33-8

Formula: C₁₅H₁₄ClN₃O₄S₃

Color and Shape: Neat

Molecular weight: 431.94

Ref: 86-MM1716.00

Benzthiazide

Controlled Product

CAS: 91-33-8

Applications Benzthiazide is a diuretic, antihypertensive agent.
References Mollica, J., et al.: J. Pharm. Sci., 58, 635 (1969), Chienthavorn, O., et al.: J. Pharm. Biomed. Anal., 36, 477 (2004),

Formula: C₁₅H₁₄ClN₃O₄S₃

Color and Shape: Neat

Molecular weight: 431.94

Ref: TR-B209925

Benzthiazide

CAS: 91-33-8

Color and Shape: Neat

Ref: 61-FOR1716.00