CAS 91-80-5

Methapyrilene

Description:

Methapyrilene is an antihistamine and sedative belonging to the class of compounds known as alkylamines. It is primarily used for its antihistaminic properties, which help alleviate allergic reactions and symptoms such as sneezing, runny nose, and itching. Methapyrilene is characterized by its ability to cross the blood-brain barrier, which contributes to its sedative effects. The compound has a relatively low solubility in water but is soluble in organic solvents, making it suitable for various pharmaceutical formulations. Methapyrilene's mechanism of action involves antagonism of H1 histamine receptors, thereby inhibiting the physiological effects of histamine. While it has been utilized in some over-the-counter medications, its use has declined due to concerns about potential side effects, including sedation and anticholinergic effects. As with many antihistamines, caution is advised when using methapyrilene, particularly in populations sensitive to sedative effects, such as the elderly or those operating machinery.

Formula: C₁₄H₁₉N₃S

InChI: InChI=1S/C14H19N3S/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14/h3-8,11H,9-10,12H2,1-2H3

InChI key: InChIKey=HNJJXZKZRAWDPF-UHFFFAOYSA-N

SMILES: N(CC1=CC=CS1)(CCN(C)C)C2=CC=CC=N2

Synonyms:

• 1,2-Ethanediamine, N,N-dimethyl-N′-2-pyridinyl-N′-(2-thienylmethyl)-
• 1,2-Ethanediamine, N¹,N¹-dimethyl-N²-2-pyridinyl-N²-(2-thienylmethyl)-
• 2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine
• A 3322
• Ah 42
• Dimethyl[2-[(pyridin-2-yl)[(thien-2-yl)methyl]amino]ethyl]amine
• Histadryl
• Lulamin
• Metapyrilene
• N,N-Dimethyl-N′-pyrid-2-yl-N′-2-thenylethylenediamine
• N,N-dimethyl-N-2-pyridyl-N-2-thenylethylenediamine
• N-(α-Pyridyl)-N-(α-thenyl)-N′,N′-dimethylethylenediamine
• N¹,N¹-Dimethyl-N²-2-pyridinyl-N²-(2-thienylmethyl)-1,2-ethanediamine
• Paradormalene
• Pyridine, 2-[[2-(dimethylamino)ethyl]-2-thenylamino]-
• Pyrinistab
• Pyrinistol
• Rest-on
• Restryl
• Semikon
• Sleepwell
• Tenalin
• Thenylene
• Thenylpyramine
• Thionylan
• 1,2-Ethanediamine, N1,N1-dimethyl-N2-2-pyridinyl-N2-(2-thienylmethyl)-

Methapyrilene

Controlled Product

CAS: 91-80-5

Applications Methapyrilene is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.
References Calandre, E.P., et al.: Clin. Pharmacol. Ther., 29, 527 (1981); Eastmond, D., et al.: Mutagenesis, 24, 341 (2009); Dertinger, S., et al.: Toxicol. Sci., 115, 401 (2010)

Formula: C₁₄H₁₉N₃S

Color and Shape: Colourless To Yellow

Molecular weight: 261.39

Ref: TR-M259998

Methapyrilene Dihydrochloride

Controlled Product

CAS: 91-80-5

Applications Methapyrilene Dihydrochloride is a hydrochloric salt derivative of methylpyrilene which is used as antihistaminic agent.
References Calandre, E.P., et al.: Clin. Pharmacol. Ther., 29, 527 (1981), Eastmond, D., et al.: Mutagenesis, 24, 341 (2009), Dertinger, S., et al.: Toxicol. Sci., 115, 401 (2010),

Formula: C₁₄H₁₉N₃S·2(HCl)

Color and Shape: Neat

Molecular weight: 261.39 + (36.46)

Ref: TR-M259945

Methapyrilene dihydrochloride

CAS: 91-80-5

Methapyrilene dihydrochloride is an anticancer drug that acts as a kinase inhibitor, preventing the activation of protein kinases that are involved in cancer cell growth and survival. It has been shown to induce apoptosis (cell death) in cancer cells by inhibiting the activity of certain kinases. Methapyrilene dihydrochloride is a potent inhibitor of tumor growth in Chinese hamsters, human tumors, and other animal models. It is also an analog of amphetamine and can be detected in urine tests. This drug has shown promising results as a potential treatment for various types of cancer.

Formula: C₁₄H₁₉N₃S

Purity: Min. 95%

Molecular weight: 261.39 g/mol

Ref: 3D-AAA09180

Methapyrilene

CAS: 91-80-5

Methapyrilene is a histamine H1 antagonist with sedative action.

Formula: C₁₄H₁₉N₃S

Color and Shape: Liquid Physical Description Clear Colorless Liquid (Ntp 1992)

Molecular weight: 261.39

Ref: TM-T28026