CAS 910297-53-9

{4-[6-({5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazol-2-yl}amino)-2-methylpyrimidin-4-yl]piperazin-1-yl}acetic acid

Description:

The chemical substance known as 4-[6-({5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazol-2-yl}amino)-2-methylpyrimidin-4-yl]piperazin-1-yl}acetic acid, with the CAS number 910297-53-9, is a complex organic compound characterized by its multi-functional structure. It features a piperazine ring, which is a common motif in pharmacologically active compounds, and is linked to a pyrimidine and thiazole moiety, indicating potential biological activity. The presence of a chloro group and a carbamoyl substituent suggests that it may interact with biological targets through hydrogen bonding and hydrophobic interactions. This compound is likely to exhibit solubility in polar solvents due to its carboxylic acid functional group, which can also influence its pharmacokinetic properties. Its intricate structure may contribute to specific interactions with biological receptors, making it a candidate for further investigation in medicinal chemistry. Overall, the compound's unique arrangement of functional groups positions it as a potentially valuable entity in drug development and therapeutic applications.

Formula: C₂₂H₂₄ClN₇O₃S

InChI: InChI=1/C22H24ClN7O3S/c1-13-4-3-5-15(23)20(13)28-21(33)16-11-24-22(34-16)27-17-10-18(26-14(2)25-17)30-8-6-29(7-9-30)12-19(31)32/h3-5,10-11H,6-9,12H2,1-2H3,(H,28,33)(H,31,32)(H,24,25,26,27)

SMILES: Cc1cccc(c1N=C(c1cnc(Nc2cc(nc(C)n2)N2CCN(CC2)CC(=O)O)s1)O)Cl

4-[6-[[5-[[(2-CHLORO-6-METHYLPHENYL)AMINO]CARBONYL]-THIAZOL-2-YL]AMINO]-2-METHYL-PYRIMIDIN-4-YL]-1-PIPERAZINEACETIC ACID

CAS: 910297-53-9

Formula: C₂₂H₂₄ClN₇O₃S

Purity: 99.23%

Color and Shape: Solid

Molecular weight: 501.9891

Ref: IN-DA006FJD

Dasatinib Carboxylic Acid

CAS: 910297-53-9

Formula: C₂₂H₂₄ClN₇O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 502.00

Ref: 4Z-D-3020

Dasatinib metabolite M6

CAS: 910297-53-9

M6, an oxidative metabolite of Dasatinib, is a potent oral inhibitor of Bcr-Abl and Src tyrosine kinases.

Formula: C₂₂H₂₄ClN₇O₃S

Color and Shape: Solid

Molecular weight: 501.99

Ref: TM-T37645

Dasatinib Carboxylic Acid

Controlled Product

CAS: 910297-53-9

Applications An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.
References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),

Formula: C₂₂H₂₄ClN₇O₃S

Color and Shape: Light Yellow

Molecular weight: 501.99

Ref: TR-D193605

Dasatinib Carboxylic Acid

CAS: 910297-53-9

Formula: C₂₂H₂₄ClN₇O₃S

Molecular weight: 501.99

Ref: ST-EA-CP-D1001