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CAS 911-77-3

:

N-α-Benzoyl-DL-arginine-p-nitroanilide hydrochloride

Description:
N-α-Benzoyl-DL-arginine-p-nitroanilide hydrochloride, commonly referred to as BAPNA, is a synthetic compound primarily used as a substrate in biochemical assays to study proteolytic enzymes, particularly serine proteases. This compound features a benzoyl group attached to the amino acid arginine, with a p-nitroanilide moiety that serves as a chromogenic indicator. Upon enzymatic cleavage by proteases, BAPNA releases p-nitroaniline, which can be quantitatively measured due to its distinct color change, making it a valuable tool in enzyme kinetics studies. BAPNA is typically a white to off-white crystalline powder, soluble in organic solvents and slightly soluble in water. Its molecular structure contributes to its stability and reactivity, allowing for effective monitoring of enzyme activity. Additionally, as a hydrochloride salt, it exhibits enhanced solubility in aqueous solutions, facilitating its use in various laboratory applications. Proper handling and storage conditions are essential to maintain its integrity and effectiveness in experimental settings.
Formula:C19H22N6O4·ClH
InChI:InChI=1S/C19H22N6O4.ClH/c20-19(21)22-12-4-7-16(24-17(26)13-5-2-1-3-6-13)18(27)23-14-8-10-15(11-9-14)25(28)29;/h1-3,5-6,8-11,16H,4,7,12H2,(H,23,27)(H,24,26)(H4,20,21,22);1H
InChI key:InChIKey=DEOKFPFLXFNAON-UHFFFAOYSA-N
SMILES:N(C(C(NC(=O)C1=CC=CC=C1)CCCNC(=N)N)=O)C2=CC=C(N(=O)=O)C=C2.Cl
Synonyms:
  • Benzamide, N-[4-[(aminoiminomethyl)amino]-1-[[(4-nitrophenyl)amino]carbonyl]butyl]-, hydrochloride (1:1)
  • Benzamide, N-[4-[(aminoiminomethyl)amino]-1-[[(4-nitrophenyl)amino]carbonyl]butyl]-, monohydrochloride
  • N-Benzoyl-Dl-Arginine-4-Nitroanilide Hydrochloride
  • N-α-Benzoyl-<span class="text-smallcaps">D</smallcap><smallcap>L</span>-arginine-p-nitroanilide hydrochloride
  • N<sup>α</sup>-Benzoyl-<span class="text-smallcaps">D</smallcap><smallcap>L</span>-arginine-p-nitroanilide hydrochloride
  • NSC 83264
  • Valeranilide, 2-benzamido-5-guanidino-4′-nitro-, monohydrochloride, <span class="text-smallcaps">DL</span>-
  • Nα-Benzoyl-DL-arginine-p-nitroanilide hydrochloride
  • Valeranilide, 2-benzamido-5-guanidino-4′-nitro-, monohydrochloride, DL-
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