CAS 91101-00-7

1-methyl-2'-O-methyladenosine

Description:

1-Methyl-2'-O-methyladenosine is a modified nucleoside derived from adenosine, characterized by the presence of a methyl group at the 1-position of the adenine base and a methoxy group at the 2'-position of the ribose sugar. This modification can influence the stability and function of RNA molecules, particularly in the context of post-transcriptional modifications. The presence of the 2'-O-methyl group is known to enhance the resistance of RNA to enzymatic degradation, which can be beneficial in various biological processes, including RNA splicing and translation. Additionally, 1-methyl-2'-O-methyladenosine may play a role in regulating gene expression and cellular signaling pathways. Its unique structural features contribute to its potential applications in biochemistry and molecular biology, particularly in the development of therapeutic agents and RNA-based technologies. The compound is typically studied in the context of RNA modifications and their implications in cellular function and disease.

Formula: C₁₂H₁₇N₅O₄

InChI: InChI=1/C12H19N5O4/c1-16-4-15-11-7(10(16)13)14-5-17(11)12-9(20-2)8(19)6(3-18)21-12/h5-6,8-9,12,18-19H,3-4,13H2,1-2H3/t6-,8-,9-,12-/m1/s1

SMILES: CN1CN=c2c(=C1N)ncn2[C@H]1[C@@H]([C@@H]([C@@H](CO)O1)O)OC

Synonyms:

• Adenosine, 1-methyl-2'-O-methyl-
• 2'-O-Methyl-N1-methyladenosine
• 2'-O-methyl-1-methyladenosine
• 1,2'-O-dimethyladenosine
• N1,O2'-Dimethyladenosine
• (2R,3R,4R,5R)-5-(6-amino-1-methyl-2H-purin-9-yl)-2-(hydroxymethyl)-4-m ethoxy-oxolan-3-ol

2'-O-Methyl-N1-methyladenosine

CAS: 91101-00-7

Nucleoside Derivatives - N-Alkylated nucleosides; 2’-Modified nucleosides; Naturally modified ribo-nucloesides

Formula: C₁₂H₁₇N₅O₄

Color and Shape: Solid

Molecular weight: 295.29

Ref: TM-TNU0471

N1,O2'-Dimethyladenosine

CAS: 91101-00-7

Formula: C₁₂H₁₇N₅O₄

Color and Shape: Neat

Molecular weight: 295.29

Ref: TR-D447410

N1,O2'-Dimethyladenosine

CAS: 91101-00-7

N1,O2'-Dimethyladenosine is a monophosphate that is an antiviral agent. It has been shown to be a potent activator of the tRNA synthetase enzyme and also inhibits viral DNA synthesis. This drug is synthesized from diphosphate and phosphoramidites. N1,O2'-Dimethyladenosine has been shown to be highly active against viruses such as HIV-1, HIV-2, and HCV. It is also used in the production of modified nucleosides for use in synthetic constructs with therapeutic applications.

Formula: C₁₂H₁₇N₅O₄

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 295.29 g/mol

Ref: 3D-ND159412

N1,O2'-Dimethyladenosine-d3 Monohydriodide

Controlled Product

CAS: 59867-24-2, 91101-00-7

Applications N1,O2'-Dimethyladenosine-d3 Monohydriodide is an intermediate in the synthesis of N6,O2'-Dimethyladenosine-d3 (D447417). N6,O2'-Dimethyladenosine-d3 is an isotopic analog of N6,O2'-Dimethyladenosine (D447415), a naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007)

Formula: C₁₂D₃H₁₅N₅O₄·I

Color and Shape: Neat

Molecular weight: 426.225

Ref: TR-D447414

N1,O2'-Dimethyladenosine-d3

Controlled Product

CAS: 91101-00-7

Applications N1,O2'-Dimethyladenosine-d3, is the labeled analogue of N1,O2'-Dimethyladenosine (D447410), which is a naturally occurring modified ribonucleotide found in tRNA.
References Xu, Y., et al.: J. Comput. Chem., 37, 896 (2016);

Formula: C₁₂D₃H₁₄N₅O₄

Color and Shape: Neat

Molecular weight: 298.313

Ref: TR-D447413

N1,O2'-Dimethyladenosine-d3 Monohydriodide

Controlled Product

CAS: 59867-24-2, 91101-00-7

Applications N1,O2'-Dimethyladenosine Monohydriodide-d3, is the labeled a analogue of N1,O2'-Dimethyladenosine Monohydriodide (D447411), is an intermediate useful in the synthesis of N6,O2'-Dimethyladenosine (D447415), which is naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);

Formula: C₁₂D₃H₁₅N₅O₄·I

Color and Shape: Neat

Molecular weight: 426.225

Ref: TR-D447412