CAS 911222-45-2

Rabusertib

Description:

Rabusertib, with the CAS number 911222-45-2, is a small molecule inhibitor primarily targeting the protein kinase AKT, which plays a crucial role in various cellular processes, including metabolism, proliferation, and survival. This compound is classified as a selective inhibitor, meaning it specifically disrupts the activity of AKT without significantly affecting other kinases. Rabusertib has been investigated for its potential therapeutic applications in cancer treatment, particularly in tumors with aberrant AKT signaling pathways. Its mechanism of action involves the inhibition of downstream signaling cascades that promote tumor growth and survival, making it a candidate for combination therapies. In preclinical and clinical studies, Rabusertib has shown promise in enhancing the efficacy of other anticancer agents. The compound is typically administered orally and has undergone various phases of clinical trials to evaluate its safety, tolerability, and effectiveness in different cancer types. As with many investigational drugs, ongoing research continues to elucidate its full therapeutic potential and any associated side effects.

Formula: C₁₈H₂₂BrN₅O₃

Synonyms:

• 1-(5-bromo-4-methyl-2-{[(2S)-morpholin-2-yl]methoxy}phenyl)-3-(5-methylpyrazin-2-yl)urea
• 1-[5-bromo-4-methyl-2-S-(morpholin-2-yl-methoxy)-phenyl]-3-(5-methyl-pyrazin-2-yl)-urea
• 1-{5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl}-3-(5-methyl-2-pyrazinyl)urea
• 3-{5-bromo-4-methyl-2-[(2S)-morpholin-2-ylmethoxy]phenyl}-1-(5-methylpyrazin-2-yl)urea
• Ly-2603618
• Ly2603618
• IC-83
• LY2603618, >=99%
• (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
• 3-(5-BroMo-4-Methyl-2-[(2s)-Morpholin-2-
• Rabusertib
• ly2603618 IC-83
• N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)urea LY 2603618

LY2603618

CAS: 911222-45-2

Formula: C₁₈H₂₂BrN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 436.3030

Ref: IN-DA00GU45

Rabusertib

CAS: 911222-45-2

Rabusertib

Purity: ≥98%

Molecular weight: 436.3g/mol

Ref: 54-BUP15451

(S)-1-(5-Bromo-4-Methyl-2-(Morpholin-2-Ylmethoxy)Phenyl)-3-(5-Methylpyrazin-2-Yl)Urea

CAS: 911222-45-2

(S)-1-(5-Bromo-4-Methyl-2-(Morpholin-2-Ylmethoxy)Phenyl)-3-(5-Methylpyrazin-2-Yl)Urea

Purity: 98%

Molecular weight: 436.3g/mol

Ref: 54-OR1024293

Rabusertib (LY2603618)

CAS: 911222-45-2

Formula: C₁₈H₂₂N₅O₃

Color and Shape: Brown Solid

Molecular weight: 436.31

Ref: 4Z-K-031049

Rabusertib

CAS: 911222-45-2

Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.

Formula: C₁₈H₂₂BrN₅O₃

Purity: 98.86% - 99.87%

Color and Shape: Solid

Molecular weight: 436.3

Ref: TM-T6084

Rabusertib

CAS: 911222-45-2

Purity: 98%

Molecular weight: 436.31

Ref: 10-F979706

LY 2603618

CAS: 911222-45-2

Inhibitor of Chk1 kinase; anti-neoplastic

Formula: C₁₈H₂₂BrN₅O₃

Purity: Min. 95%

Molecular weight: 436.3 g/mol

Ref: 3D-BL166662