CAS 91224-37-2

(D-arg1,D-trp7,9,leu11)-substance P*acetate

Description:

(D-arg1,D-trp7,9,leu11)-substance P*acetate, with the CAS number 91224-37-2, is a synthetic analog of substance P, a neuropeptide involved in various physiological processes, including pain perception and inflammation. This compound is characterized by its modified amino acid sequence, which includes D-arginine at position 1, D-tryptophan at positions 7 and 9, and leucine at position 11, enhancing its stability and receptor binding affinity compared to the natural peptide. The acetate component indicates that the compound is in its acetate salt form, which can influence its solubility and bioavailability. Typically, such analogs are studied for their potential therapeutic applications, particularly in pain management and neurobiology, due to their ability to interact with neurokinin receptors. The structural modifications aim to improve pharmacological properties while reducing susceptibility to enzymatic degradation. Overall, this compound represents a significant interest in medicinal chemistry and pharmacology for developing new treatments targeting neuropeptide pathways.

Formula: C₇₅H₁₀₈N₂₀O₁₃

InChI: InChI=1/C75H108N20O13/c1-42(2)35-55(64(80)98)89-67(101)56(36-43(3)4)90-69(103)59(39-46-41-85-51-23-11-9-20-48(46)51)93-68(102)57(37-44-17-6-5-7-18-44)91-70(104)58(38-45-40-84-50-22-10-8-19-47(45)50)92-66(100)52(27-29-62(78)96)86-65(99)53(28-30-63(79)97)87-71(105)61-26-16-34-95(61)74(108)54(24-12-13-31-76)88-72(106)60-25-15-33-94(60)73(107)49(77)21-14-32-83-75(81)82/h5-11,17-20,22-23,40-43,49,52-61,84-85H,12-16,21,24-39,76-77H2,1-4H3,(H2,78,96)(H2,79,97)(H2,80,98)(H,86,99)(H,87,105)(H,88,106)(H,89,101)(H,90,103)(H,91,104)(H,92,100)(H,93,102)(H4,81,82,83)/t49-,52?,53+,54+,55+,56?,57+,58-,59-,60?,61?/m1/s1

Synonyms:

• (D-Arg1,D-Trp79,Leu11)-Substance P
• H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
• D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride

(D-Arg¹,D-Trp⁷·⁹,Leu¹¹)-Substance P

CAS: 91224-37-2

Spantide I, a high potency substance P antagonist with a weak spasmogenic and a poor histamine releasing effect.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purity: 95.2%

Color and Shape: Beige Powder

Molecular weight: 1497.81

Ref: 01-4004691

[D-Arg1, D-Trp7,9, Leu11]-Substance P

CAS: 91224-37-2

Formula: C₇₅H₁₀₈N₂₀O₁₃

Molecular weight: 1497.79

Ref: 7W-GL0691

Spantide I

CAS: 91224-37-2

Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 1497.79

Ref: TM-T20413

[D-Arg1,D-Trp7,9,Leu11]-Substance P

CAS: 91224-37-2

This product is a Substance P antagonist in the Hydrochloride salt from and as a 0.5mg vial. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purity: Min. 95%

Molecular weight: 1,497.8 g/mol

Ref: 3D-PSP-4173-V

(D-Arg1,D-Trp7·9,Leu11)-Substance P

CAS: 91224-37-2

Substance P is a neuropeptide that is involved in the transmission of pain signals from the nerves to the brain. It also has been implicated in inflammatory and autoimmune diseases. Substance P is a potent agonist of the neurokinin-1 receptor, which causes an increase in intracellular calcium ion levels, leading to neuronal excitation. The release of substance P from nerve fibers can be blocked by administration of an analog (e.g., N-acetyl-D-Arg1,D-Trp7·9,Leu11)-substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu -Leu -NH2). This compound blocks the activation of substance P receptors with high affinity and specificity.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purity: Min. 95%

Molecular weight: 1,497.79 g/mol

Ref: 3D-FA108555