CAS 912273-65-5

Edoxaban tosylate

Description:

Edoxaban tosylate is an anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. It functions as a direct factor Xa inhibitor, which means it selectively inhibits the activity of factor Xa, an essential component in the coagulation cascade, thereby preventing the formation of blood clots. The tosylate salt form enhances its solubility and stability. Edoxaban is characterized by its high bioavailability and a relatively short half-life, allowing for once-daily dosing. It is typically administered orally and is well-absorbed in the gastrointestinal tract. The drug's pharmacokinetics can be influenced by factors such as renal function and body weight, necessitating careful monitoring in certain populations. Common side effects may include bleeding complications, which are a risk associated with all anticoagulants. Overall, Edoxaban tosylate represents a significant advancement in anticoagulant therapy, offering a balance of efficacy and safety for patients at risk of thrombotic events.

Formula: C₂₄H₃₀ClN₇O₄S·C₇H₈O₃S

InChI: InChI=1S/C24H30ClN7O4S.C7H8O3S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23;1-6-2-4-7(5-3-6)11(8,9)10/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34);2-5H,1H3,(H,8,9,10)/t13-,15-,17+;/m0./s1

InChI key: InChIKey=ZLFZITWZOYXXAW-QXXZOGQOSA-N

SMILES: N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3.S(=O)(=O)(O)C1=CC=C(C)C=C1

Synonyms:

• DU 176b
• Edoxaban tosylate
• Ethanediamide, N-(5-chloro-2-pyridinyl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, mono(4-methylbenzenesulfonate)
• Ethanediamide, N¹-(5-chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate (1:1)
• Lixiana
• N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
• Roteas
• Savaysa
• Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate (1:1)