CAS 912444-00-9

Veliparib

Description:

Veliparib, also known by its chemical name ABT-888, is a small molecule inhibitor primarily targeting poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair processes. Its chemical formula is C19H22N4O3, and it is classified as a benzamide derivative. Veliparib exhibits characteristics such as being a white to off-white solid with moderate solubility in organic solvents. It is primarily investigated for its potential in cancer therapy, particularly in tumors with deficiencies in DNA repair mechanisms, such as those with BRCA mutations. By inhibiting PARP, Veliparib enhances the cytotoxic effects of DNA-damaging agents, making it a candidate for combination therapies in oncology. The substance has undergone various clinical trials to assess its efficacy and safety profile in treating different types of cancers, including breast and ovarian cancers. As with many pharmacological agents, its use may be associated with side effects, which are important to consider in therapeutic contexts.

Formula: C₁₃H₁₆N₄O·2ClH

InChI: InChI=1/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1

InChI key: InChIKey=JNAHVYVRKWKWKQ-CYBMUJFWSA-N

SMILES: C(N)(=O)C1=C2C(N=C(N2)[C@@]3(C)CCCN3)=CC=C1

Synonyms:

• 1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-
• 1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-
• 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide
• 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
• 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide
• 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
• A 861695
• A861695
• Abt 888
• Abt888
• Unii-01O4K0631N
• Veliparib
• Veliparib ER
• 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
• (S)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide
• (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (VELIPARIB)
• 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide Veliparib (ABT-888)
• ABT-888 2HCl
• ABT-888,Veliparib
• ABT-888 (Veliparib, NSC 737664)
• carboxamide
• Veliparib(chiral)
• (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]iMidazole-4-carboxaMide

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide

CAS: 912444-00-9

Formula: C₁₃H₁₆N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 244.2923

Ref: IN-DA0039KX

Veliparib

CAS: 912444-00-9

Veliparib

Purity: ≥98%

Molecular weight: 244.29g/mol

Ref: 54-BUP15499

Veliparib

CAS: 912444-00-9

Veliparib

Purity: 99%

Molecular weight: 244.29g/mol

Ref: 54-OR1024584

Veliparib

CAS: 912444-00-9

Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.

Formula: C₁₃H₁₆N₄O

Purity: 98.66% - 99%

Color and Shape: Solid

Molecular weight: 244.29

Ref: TM-T2591

Veliparib, Free Base

CAS: 912444-00-9

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 244.29800415039062

Ref: 10-F519795

ABT 888

Controlled Product

CAS: 912444-00-9

Applications ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.
References Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002), Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2003), Kim, M., et al.: Cell, 119, 803 (2004), Tentori, L., et al.: Pharmacol. Res., 52, 25 (2005),

Formula: C₁₃H₁₆N₄O

Color and Shape: Neat

Molecular weight: 244.29

Ref: TR-A112580

Veliparib

CAS: 912444-00-9

Potently inhibits PARP-1 and PARP-2 enzymes, orally bioavailable and crosses blood-brain barrier. Sensitises cancer cells to DNA-damaging chemotherapy and radiotherapy. Combination therapies investigated in clinical trials for solid and blood malignancies.

Formula: C₁₃H₁₆N₄O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 244.29 g/mol

Ref: 3D-FV16903