CAS 912569-84-7

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine

Description:

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine, identified by its CAS number 912569-84-7, is a synthetic derivative of maytansine, a potent antitumor agent originally derived from the plant Maytenus serrata. This compound exhibits characteristics typical of maytansine analogs, including its ability to inhibit microtubule polymerization, which disrupts mitotic spindle formation and ultimately leads to cell cycle arrest and apoptosis in cancer cells. The presence of a methylthio group and an oxopropyl moiety enhances its biological activity and specificity. As a targeted therapeutic, it is often explored in the context of antibody-drug conjugates (ADCs), where it can be linked to antibodies for selective delivery to tumor cells, minimizing systemic toxicity. The compound's stability, solubility, and pharmacokinetic properties are critical for its efficacy in clinical applications. Overall, N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine represents a promising candidate in cancer therapy, particularly in the development of novel ADCs.

Formula: C₃₆H₅₀ClN₃O₁₀S

Synonyms:

• N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine (>90%)
• N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine
• S-methyl DM1

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine

Controlled Product

CAS: 912569-84-7

Applications N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is an active metabolite of Maytansine (M197940), inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer.
References Remillard, S., et. al.: Science, 189, 1002 (1975); Prota, A.E., et. al.: P. Natl. Acad. Sci. USA, 111, 13817 (2014)

Formula: C₃₆H₅₀ClN₃O₁₀S

Purity: >90%

Color and Shape: Neat

Molecular weight: 752.31

Ref: TR-D199035

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine-d3

Controlled Product

CAS: 912569-84-7

Applications Isotope labelled N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is an active metabolite of Maytansine (M197940), inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer.
References Remillard, S., et. al.: Science, 189, 1002 (1975); Prota, A.E., et. al.: P. Natl. Acad. Sci. USA, 111, 13817 (2014)

Formula: C₃₆H₄₇D₃ClN₃O₁₀S

Color and Shape: Neat

Molecular weight: 755.33

Ref: TR-D199037

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine

CAS: 912569-84-7

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is a cytotoxic drug that belongs to the class of maytansinoids. It is metabolized in vivo to produce cytotoxic metabolites which inhibit protein synthesis by binding to ribosomes, preventing peptide bond formation. The preclinical studies have shown that N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine has a better therapeutic index than other maytansinoids, with fewer side effects. In animal models, N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine showed efficacy against human tumor cells and was not toxic to normal cells. This agent also showed no impurities when incubated with human liver microsomes and it was well tolerated in clinical trials in humans

Formula: C₃₆H₅₀ClN₃O₁₀S

Purity: Min. 95%

Molecular weight: 752.3 g/mol

Ref: 3D-MLB56984

S-methyl DM1

CAS: 912569-84-7

S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.

Formula: C₃₆H₅₀ClN₃O₁₀S

Purity: 98%

Color and Shape: Solid

Molecular weight: 752.31

Ref: TM-T12805