CAS 91392-33-5

1-(4-nitrophenyl)cyclopentanecarbonitrile

Description:

1-(4-Nitrophenyl)cyclopentanecarbonitrile is an organic compound characterized by its unique structure, which includes a cyclopentane ring and a nitrophenyl group. The presence of the cyano group (-C≡N) contributes to its reactivity and polarity, making it a useful intermediate in organic synthesis. The nitro group (-NO2) attached to the phenyl ring enhances the compound's electron-withdrawing properties, influencing its chemical behavior and potential applications in various reactions, such as nucleophilic substitutions or electrophilic aromatic substitutions. This compound is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. Its properties, such as melting point, boiling point, and spectral characteristics, can vary based on purity and environmental conditions. Due to its structural features, it may also exhibit biological activity, making it of interest in medicinal chemistry. Safety precautions should be taken when handling this compound, as nitro compounds can be hazardous. Overall, 1-(4-nitrophenyl)cyclopentanecarbonitrile serves as a valuable building block in synthetic organic chemistry.

Formula: C₁₂H₁₂N₂O₂

InChI: InChI=1/C12H12N2O2/c13-9-12(7-1-2-8-12)10-3-5-11(6-4-10)14(15)16/h3-6H,1-2,7-8H2

SMILES: C1CCC(C1)(C#N)c1ccc(cc1)N(=O)=O

Synonyms:

• Cyclopentanecarbonitrile, 1-(4-nitrophenyl)-
• 1-(4-Nitrophenyl)cyclopentanecarbonitrile
• 1-(4-nitrophenyl)cyclopentane-1-carbonitrile

1-(4-Nitro-phenyl)-cyclopentanecarbonitrile

CAS: 91392-33-5

Formula: C₁₂H₁₂N₂O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 216.2359

Ref: IN-DA006BHC

1-(4-Nitrophenyl)cyclopentanecarbonitrile

CAS: 91392-33-5

1-(4-Nitrophenyl)cyclopentanecarbonitrile

Purity: 95%

Molecular weight: 216.24g/mol

Ref: 54-OR470030

1-(4-Nitrophenyl)cyclopentane-1-carbonitrile

CAS: 91392-33-5

Purity: 95%

Molecular weight: 216.2400055

Ref: 10-F720682

1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8

Controlled Product

CAS: 91392-33-5

Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Formula: C₁₂D₈H₄N₂O₂

Color and Shape: Neat

Molecular weight: 224.285

Ref: TR-N546636