CAS 91421-42-0

Rubitecan

Description:

Rubitecan, also known by its chemical name, is a synthetic compound classified as a topoisomerase inhibitor, primarily used in cancer therapy. It is characterized by its ability to interfere with the DNA replication process, making it effective against various types of tumors. The compound exhibits a unique structure that allows it to bind to the enzyme topoisomerase I, preventing the enzyme from performing its normal function of relieving torsional strain during DNA replication. This action leads to DNA damage and ultimately induces apoptosis in cancer cells. Rubitecan is typically administered in a clinical setting, and its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through the biliary system. The substance has been studied for its efficacy in treating specific cancers, although its use may be limited by potential side effects, including myelosuppression and gastrointestinal disturbances. As with any chemotherapeutic agent, careful monitoring and management of adverse effects are essential during treatment.

Formula: C₂₀H₁₅N₃O₆

InChI: InChI=1/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1

InChI key: InChIKey=VHXNKPBCCMUMSW-FQEVSTJZSA-N

SMILES: O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=CC4N(=O)=O)=CC5=C1COC(=O)[C@@]5(CC)O

Synonyms:

• (4R)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (S)-
• 4-ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 9-Nitro-20(S)-camptothecin
• 9-Nitrocamptothecin
• 9-Nitrocellulose camptothecine
• Orathecin
• Rfs 2000
• 9-NC
• CAMPTOTHECIN, 9-NITRO-20(S)-
• 9-NITRO-CPT
• RUBITECAN
• Oratheci
• Rubitecane
• RUBETICAN

Rubitecan

CAS: 91421-42-0

Formula: C₂₀H₁₅N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 393.3496

Ref: IN-DA003NLJ

Rubitecan

CAS: 91421-42-0

Rubitecan

Purity: ≥95%

Molecular weight: 393.35g/mol

Ref: 54-BUP10315

Rubitecan

CAS: 91421-42-0

Formula: C₂₀H₁₅N₃O₆

Molecular weight: 393.35

Ref: 7W-GP1102

Rubitecan

CAS: 91421-42-0

Formula: C₂₀H₁₅N₃O₆

Purity: 95%~99%

Molecular weight: 393.355

Ref: BP-BP1229

9-Nitrocamptothecin

CAS: 91421-42-0

Formula: C₂₀H₁₅N₃O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Yellow powder to crystal

Molecular weight: 393.36

Ref: 3B-N0822

Rubitecan

CAS: 91421-42-0

Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.

Formula: C₂₀H₁₅N₃O₆

Purity: 97.54%

Color and Shape: Yellow Amorphous Powder

Molecular weight: 393.35

Ref: TM-T5853

Rubitecan

CAS: 91421-42-0

Topoisomerase I inhibitor

Formula: C₂₀H₁₅N₃O₆

Purity: Min. 95%

Molecular weight: 393.35 g/mol

Ref: 3D-FR27767

Rubitecan

Controlled Product

CAS: 91421-42-0

Applications Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.
References Stehlin, J.S., et al.: Int. J. Oncol., 14, 821 (1999), Verschraegen, C.F., et al.: Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs, 1, 184 (1999),

Formula: C₂₀H₁₅N₃O₆

Color and Shape: Neat

Molecular weight: 393.35

Ref: TR-R701500