CAS 91421-42-0: Rubitecan

Description: Rubitecan, also known by its chemical name, is a synthetic compound classified as a topoisomerase inhibitor, primarily used in cancer therapy. It is characterized by its ability to interfere with the DNA replication process, making it effective against various types of tumors. The compound exhibits a unique structure that allows it to bind to the enzyme topoisomerase I, preventing the enzyme from performing its normal function of relieving torsional strain during DNA replication. This action leads to DNA damage and ultimately induces apoptosis in cancer cells. Rubitecan is typically administered in a clinical setting, and its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through the biliary system. The substance has been studied for its efficacy in treating specific cancers, although its use may be limited by potential side effects, including myelosuppression and gastrointestinal disturbances. As with any chemotherapeutic agent, careful monitoring and management of adverse effects are essential during treatment.

Formula: C₂₀H₁₅N₃O₆

InChI: InChI=1/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1

InChI key: InChIKey=VHXNKPBCCMUMSW-FQEVSTJZSA-N

SMILES: O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=CC=C(C5=CC4C3)N(=O)=O

Synonyms:

• (4R)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (S)-
• 4-ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 9-Nitro-20(S)-camptothecin
• 9-Nitrocamptothecin
• 9-Nitrocellulose camptothecine
• Orathecin
• Rfs 2000
• 9-NC
• CAMPTOTHECIN, 9-NITRO-20(S)-
• 9-NITRO-CPT
• RUBITECAN
• Oratheci
• Rubitecane
• RUBETICAN
• (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[346,7]indolizinol[1,2-b]quinoline-3,14(4H,-12H)-dione

Rubitecan

CAS: 91421-42-0

• Formula: C₂₀H₁₅N₃O₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 393.3496

Rubitecan

CAS: 91421-42-0

• Purity: ≥95%
• Molecular weight: 393.35g/mol

Rubitecan

CAS: 91421-42-0

• Formula: C₂₀H₁₅N₃O₆
• Molecular weight: 393.35

Rubitecan

CAS: 91421-42-0

• Formula: C₂₀H₁₅N₃O₆
• Purity: 95%~99%
• Molecular weight: 393.355

9-Nitrocamptothecin

CAS: 91421-42-0

• Formula: C₂₀H₁₅N₃O₆
• Purity: >98.0%(HPLC)
• Color and Shape: White to Yellow powder to crystal
• Molecular weight: 393.36

Rubitecan

CAS: 91421-42-0

Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.

• Formula: C₂₀H₁₅N₃O₆
• Purity: 97.54%
• Color and Shape: Yellow Amorphous Powder
• Molecular weight: 393.35

Rubitecan

CAS: 91421-42-0

Topoisomerase I inhibitor

• Formula: C₂₀H₁₅N₃O₆
• Purity: Min. 95%
• Molecular weight: 393.35 g/mol

Rubitecan

CAS: 91421-42-0

Applications Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic. References Stehlin, J.S., …

• Formula: C₂₀H₁₅N₃O₆
• Color and Shape: Neat
• Molecular weight: 393.35