CAS 91441-48-4

Teloxantrone

Description:

Teloxantrone is an anthraquinone derivative that exhibits antitumor properties, primarily used in cancer treatment. It functions as a topoisomerase II inhibitor, disrupting DNA replication and transcription, which ultimately leads to cell death in rapidly dividing cancer cells. Teloxantrone is characterized by its ability to intercalate into DNA, forming stable complexes that hinder the normal function of the genetic material. This compound is typically administered intravenously and has been investigated for its efficacy against various malignancies, including breast cancer and leukemia. Its chemical structure includes a planar aromatic system, which contributes to its interaction with DNA. While teloxantrone shows promise in oncology, its use may be associated with side effects, including myelosuppression and cardiotoxicity, necessitating careful monitoring during treatment. Ongoing research continues to explore its potential in combination therapies and its mechanisms of action to enhance therapeutic outcomes while minimizing adverse effects.

Formula: C₂₁H₂₅N₅O₄

InChI: InChI=1S/C21H25N5O4/c1-22-6-7-24-12-2-3-13-17-16(12)21(30)19-15(29)5-4-14(28)18(19)20(17)25-26(13)10-8-23-9-11-27/h2-5,22-24,27-29H,6-11H2,1H3

InChI key: InChIKey=XASBSYHEEHVCSJ-UHFFFAOYSA-N

SMILES: N(CCNC)C1=C2C=3C(C=4C(C2=O)=C(O)C=CC4O)=NN(CCNCCO)C3C=C1

Synonyms:

• Anthra[1,9-cd]pyrazol-6(2H)-one, 7,10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino)ethyl]amino]-
• 7,10-Dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino)ethyl]amino]dibenz[cd,g]indazol-6(2H)-one
• CI 937
• PD 113309
• Dibenz[cd,g]indazol-6(2H)-one, 7,10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino)ethyl]amino]-

Teloxantrone

CAS: 91441-48-4

Teloxantrone: an anthrapyrazole antibiotic inhibiting DNA replication, RNA/protein synthesis by interacting with DNA and topoisomerase II.

Formula: C₂₁H₂₅N₅O₄

Color and Shape: Solid

Molecular weight: 411.45

Ref: TM-T68372