CAS 91444-54-1

2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol

Description:

2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol, with the CAS number 91444-54-1, is an organic compound characterized by its indole structure, which is a bicyclic compound consisting of a benzene ring fused to a pyrrole ring. This substance features a hydroxyl group (-OH) attached to a phenyl group at the 4-position and a methyl group at the 3-position of the indole ring. The presence of the hydroxyl group contributes to its potential as a phenolic compound, which may exhibit antioxidant properties. The compound's structure suggests it may participate in various chemical reactions, including hydrogen bonding and π-π stacking interactions due to its aromatic nature. It may also have applications in pharmaceuticals or as a biochemical probe, although specific biological activities would depend on further empirical studies. Overall, its unique structural features make it a subject of interest in organic chemistry and medicinal research.

2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol

CAS: 91444-54-1

Applications 2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol is used as a reagent in the synthesis of tethered indoles as functionalizable ligands for estrogen receptor.
References Trogden, B.G., et al.: Bioorg. Med. Chem. Lett., 19, 485 (2009)

Formula: C₁₅H₁₃NO₂

Color and Shape: Neat

Molecular weight: 239.27

Ref: TR-H951400

2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol

CAS: 91444-54-1

2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol is a natural estrogen found in plants. It can be used as an intermediate for the synthesis of estradiol and bazedoxifene acetate. The compound has been shown to inhibit the production of estrogens by human liver cells, which may be due to its ability to bind with estrogen receptors and prevent them from binding with their natural ligand, estradiol. 2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol also inhibits the uptake of estradiol in MCF7 breast cancer cells, which may be due to its antiestrogenic activity. 2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol is not active against bazedoxifene or other antiestrogens.

Formula: CHNO

Purity: Min. 95%

Molecular weight: 239.27 g/mol

Ref: 3D-FH172742