CAS 914453-95-5

Atosiban

Description:

Atosiban is a synthetic peptide that functions as an oxytocin receptor antagonist, primarily used in obstetrics to inhibit premature labor. It is characterized by its ability to selectively block the action of oxytocin, a hormone that stimulates uterine contractions during labor. Atosiban is typically administered intravenously and is known for its relatively short half-life, necessitating careful monitoring during treatment. The compound is soluble in water, which facilitates its use in clinical settings. Its chemical structure includes a sequence of amino acids that confer its biological activity, and it is classified as a non-peptide antagonist. Atosiban's efficacy in delaying preterm labor has made it a subject of interest in maternal-fetal medicine, although its use may vary based on regional medical guidelines and practices. As with any medication, potential side effects and contraindications should be considered, and its use should be guided by a healthcare professional.

Formula: C₄₃H₆₇N₁₁O₁₂S₂

InChI: InChI=1/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36?/m0/s1

Synonyms:

• Atosiban [USAN:INN]
• Rwj 22164
• 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-threonine-8-L-ornithineoxytocin
• 1-Deamino-2D-tyr-(OEt)-4-thr-8-orn-oxytocin
• Atosibanum
• Atosibanum [INN-Latin]
• Orf 22164
• Tractocile
• Unii-081D12Si0Z
• Oxytocin, 1-(3-mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithine-
• 1-({(4R,7S,13S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-ornithylglycinamide

Atosiban acetate

CAS: 914453-95-5

Formula: C₄₅H₇₁N₁₁O₁₄S₂

Purity: %

Molecular weight: 1054.2405

Ref: IN-DA00GXEY

Atosiban Acetate

CAS: 914453-95-5

Formula: C₄₃H₆₇N₁₁O₁₂S₂·C₂H₄O₂

Color and Shape: Off-White Solid

Molecular weight: 994.19 60.05

Ref: 4Z-PA-136001

Atosiban acetate

CAS: 914453-95-5

Atosiban acetate

Purity: ≥98%

Molecular weight: 1054.24g/mol

Ref: 54-BUP10392

Atosiban Acetate

Controlled Product

CAS: 914453-95-5

Formula: C₄₃H₆₇N₁₁O₁₂S₂·C₂H₄O₂

Color and Shape: Neat

Molecular weight: 1054.24

Ref: 86-MM3515.00

Atosiban acetate

CAS: 914453-95-5

Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin.

Formula: C₄₅H₇₁N₁₁O₁₄S₂

Purity: 99.84% - 99.92%

Color and Shape: Solid

Molecular weight: 1054.24

Ref: TM-T5148

Atosiban Acetate

Controlled Product

CAS: 914453-95-5

Applications Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.
References Simsek, Y., et al.: Arch. Gynecol. Obstet., 286, 777 (2012); Mak, P., et al.: J. Psychopharmacol., 26, 532 (2012); Simsek, Y., et al.: Arch. Gynecol. Obstet., 285, 655 (2012);

Formula: C₄₃H₆₇N₁₁O₁₂S₂·C₂H₄O₂

Color and Shape: White

Molecular weight: 1054.24

Ref: TR-A791890

Atosiban Acetate

CAS: 914453-95-5

Formula: C₄₃H₆₇N₁₁O₁₂S₂C₂H₄O₂

Molecular weight: 994.2 : 60.1

Ref: ST-EA-CP-A220001

Atosiban acetate

Controlled Product

CAS: 914453-95-5

Competitive oxytocin receptor antagonist. Inhibits oxytocin-induced uterine contractions in vitro and in in vivo models of preterm labor.  Acts via Gαi signalling and activates NF-κB and MAPK pathways to elicit proinflammatory effects in the amnion.

Formula: C₄₃H₆₇N₁₁O₁₂S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 994.19 g/mol

Ref: 3D-FA40914