CAS 914453-95-5
:Atosiban
Description:
Atosiban is a synthetic peptide that functions as an oxytocin receptor antagonist, primarily used in obstetrics to inhibit premature labor. It is characterized by its ability to selectively block the action of oxytocin, a hormone that stimulates uterine contractions during labor. Atosiban is typically administered intravenously and is known for its relatively short half-life, necessitating careful monitoring during treatment. The compound is soluble in water, which facilitates its use in clinical settings. Its chemical structure includes a sequence of amino acids that confer its biological activity, and it is classified as a non-peptide antagonist. Atosiban's efficacy in delaying preterm labor has made it a subject of interest in maternal-fetal medicine, although its use may vary based on regional medical guidelines and practices. As with any medication, potential side effects and contraindications should be considered, and its use should be guided by a healthcare professional.
Formula:C43H67N11O12S2
InChI:InChI=1/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36?/m0/s1
InChI key:SVDWBHHCPXTODI-QIWYXCRTSA-N
SMILES:CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSCCC(=O)N[C@@H](C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)NCC(=O)N)CC(=O)N)[C@@H](C)O.CC(=O)O
Synonyms:- Atosiban [USAN:INN]
- Rwj 22164
- 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-threonine-8-L-ornithineoxytocin
- 1-Deamino-2D-tyr-(OEt)-4-thr-8-orn-oxytocin
- Atosibanum
- Atosibanum [INN-Latin]
- Orf 22164
- Tractocile
- Unii-081D12Si0Z
- Oxytocin, 1-(3-mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithine-
- 1-({(4R,7S,13S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-ornithylglycinamide
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Atosiban Acetate
CAS:Formula:C43H67N11O12S2·C2H4O2Color and Shape:Off-White SolidMolecular weight:994.19 60.05Atosiban Acetate
CAS:Controlled ProductFormula:C43H67N11O12S2·C2H4O2Color and Shape:NeatMolecular weight:1054.24Atosiban Acetate
CAS:Controlled ProductApplications Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.
References Simsek, Y., et al.: Arch. Gynecol. Obstet., 286, 777 (2012); Mak, P., et al.: J. Psychopharmacol., 26, 532 (2012); Simsek, Y., et al.: Arch. Gynecol. Obstet., 285, 655 (2012);Formula:C43H67N11O12S2·C2H4O2Color and Shape:NeatMolecular weight:1054.24Atosiban acetate
CAS:Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin.Formula:C45H71N11O14S2Purity:97.08% - 99.92%Color and Shape:White SolidMolecular weight:1054.24Ref: TM-T5148
5mg70.00€10mg109.00€1mL*10mM (DMSO)127.00€25mg166.00€50mg195.00€100mg254.00€500mg625.00€Atosiban acetate
CAS:Controlled ProductCompetitive oxytocin receptor antagonist. Inhibits oxytocin-induced uterine contractions in vitro and in in vivo models of preterm labor. Acts via Gαi signalling and activates NF-κB and MAPK pathways to elicit proinflammatory effects in the amnion.Formula:C43H67N11O12S2Purity:Min. 95%Color and Shape:PowderMolecular weight:994.19 g/mol
