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CAS 91449-79-5

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Heparin

Description:
Heparin is a naturally occurring anticoagulant that plays a crucial role in preventing blood clot formation. It is a highly sulfated glycosaminoglycan, primarily composed of alternating units of glucosamine and uronic acid. Heparin exhibits a strong negative charge due to its sulfate and carboxyl groups, which contributes to its ability to bind to various proteins, including antithrombin III, enhancing its anticoagulant effect. This substance is commonly used in clinical settings for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. Heparin is administered via injection, as it is not effective when taken orally due to its large molecular size and charge, which hinder absorption through the gastrointestinal tract. Its pharmacokinetics can vary based on factors such as the route of administration and patient-specific characteristics. Additionally, heparin's safety profile includes potential side effects like bleeding complications, necessitating careful monitoring during therapy. Overall, heparin remains a vital therapeutic agent in modern medicine for managing coagulation disorders.
Formula:C26H42N2O37S5
InChI:InChI=1/C26H41NO34S4/c1-4(28)27-7-9(30)8(29)6(2-52-63(43,44)45)53-24(7)56-15-10(31)11(32)25(58-19(15)21(36)37)55-13-5(3-62(40,41)42)14(60-64(46,47)48)26(59-22(13)38)57-16-12(33)17(61-65(49,50)51)23(39)54-18(16)20(34)35/h5-19,22-26,29-33,38-39H,2-3H2,1H3,(H,27,28)(H,34,35)(H,36,37)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)/t5-,6+,7+,8+,9+,10+,11+,12-,13-,14+,15-,16-,17+,18+,19-,22-,23?,24+,25+,26-/m0/s1
Synonyms:
  • 2-{2-[(5-carboxypentyl)amino]-2-oxo-1-[(phenylacetyl)amino]ethyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
  • Heparin CY 216
  • Fragmin B
  • HSDB 3094
  • Multiparin
  • Heparina
  • Hed-heparin
  • Heparinic acid
  • Clivarin
  • 1,1-diphenyl-4-(piperidin-1-yl)butan-1-ol
  • See more synonyms
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