CAS 914804-63-0

8-Iso-15-keto-PGE2

Description:

8-Iso-15-keto-PGE2 is a synthetic derivative of prostaglandin E2 (PGE2), which is a bioactive lipid involved in various physiological processes, including inflammation and regulation of blood flow. This compound is characterized by the presence of a keto group at the 15-position and an iso configuration at the 8-position, which distinguishes it from its parent compound. The structural modifications impart unique biological activities and may influence its receptor binding and signaling pathways. 8-Iso-15-keto-PGE2 is often studied for its potential roles in inflammatory responses and various disease states, including cardiovascular and gastrointestinal conditions. Its stability, solubility, and reactivity can vary based on environmental conditions, making it important for researchers to consider these factors when studying its pharmacological effects. As with many prostaglandins, it is likely to exhibit a range of biological activities, including vasodilation and modulation of immune responses, making it a compound of interest in both basic and applied biomedical research.

Formula: C₂₀H₃₀O₅

InChI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-17,19,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17+,19+/m0/s1

InChI key: InChIKey=YRTJDWROBKPZNV-RSNVZYGJSA-N

SMILES: C(/C=C\CCCC(O)=O)[C@H]1[C@@H](/C=C/C(CCCCC)=O)[C@H](O)CC1=O

Synonyms:

• (5Z,8β,11α,13E)-11-Hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid
• 8-Iso-15-keto-PGE2
• Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,8β,11α,13E)-