CAS 915038-27-6

Obeticholic Acid Impurity 2

CAS: 915038-27-6

Formula: C₂₆H₄₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 420.63

Ref: 4Z-O-056003

Obeticholic Acid-d7 (mixture of stereoisomers)

Controlled Product

CAS: 915038-27-6

Applications 6-epi-Obeticholic Acid-d7 is an intermediate used in the synthesis of 6-Ethylchenodeoxycholic-d5 Acid (E899812), which is an isotope labelled compound of 6-Ethylchenodeoxycholic Acid (E899810), which is used in the investigative treatment of primary biliary cholangitis. Primary biliary cholangitis is an autoimmune disease of the liver that slowly progresses to cirrhosis.
References Ali, A. H, et al.: Expert Opin. Orphan Drugs, 4, 1011 (2016)

Formula: C₂₆D₇H₃₇O₄

Color and Shape: White

Molecular weight: 427.668

Ref: TR-O099102

6-epi-Obeticholic Acid

Controlled Product

CAS: 915038-27-6

Formula: C₂₆H₄₄O₄

Color and Shape: Neat

Molecular weight: 420.625

Ref: TR-O099100

(3a,5b,6b,7a)-6-Ethyl-3,7-dihydroxycholan-24-oic acid

Controlled Product

CAS: 915038-27-6

(3a,5b,6b,7a)-6-Ethyl-3,7-dihydroxycholan-24-oic acid is a synthetic cholestane derivative that has been shown to be useful in the treatment of biliary cirrhosis. The synthesis of this compound involves the reduction of an ethyl ester using a grignard reagent followed by UV irradiation. The reaction yield is high with a large excess of Grignard reagent used. This compound has been shown to be active against hepatic bile ducts and liver cells in vitro. It also has anti-inflammatory effects and can be used as an alternative treatment for patients who are intolerant to ursodeoxycholic acid or chenodeoxycholic acid.

Formula: C₂₆H₄₄O₄

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 420.63 g/mol

Ref: 3D-FE171597

6-Epi-Obeticholic Acid

CAS: 915038-27-6

Formula: C₂₆H₄₄O₄

Molecular weight: 420.63

Ref: ST-EA-CP-O39013