CAS 915087-33-1

Enzalutamide

Description:

Enzalutamide is a non-steroidal anti-androgen medication primarily used in the treatment of prostate cancer. It functions by inhibiting the androgen receptor signaling pathway, which is crucial for the growth and proliferation of prostate cancer cells. The chemical formula of enzalutamide is C21H16F4N4O2, and it features a complex structure that includes a biphenyl moiety and a hydantoin ring. Enzalutamide is characterized by its high affinity for the androgen receptor, effectively blocking the action of androgens like testosterone and dihydrotestosterone. This compound is typically administered orally and is known for its favorable pharmacokinetic profile, including good bioavailability and a long half-life, allowing for once-daily dosing. Common side effects may include fatigue, hot flashes, and hypertension. Enzalutamide has been shown to improve overall survival in patients with metastatic castration-resistant prostate cancer, making it a significant therapeutic option in oncology. Its development represents a critical advancement in targeted cancer therapies, particularly in hormone-sensitive malignancies.

Formula: C₂₁H₁₆F₄N₄O₂S

InChI: InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)

InChI key: InChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N

SMILES: S=C1N(C(C)(C)C(=O)N1C2=CC(C(F)(F)F)=C(C#N)C=C2)C3=CC(F)=C(C(NC)=O)C=C3

Synonyms:

• 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide
• Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-
• Enzalutamide
• Mdv 3100
• Mdv3100
• S-Enzalutamide
• Xtandi

Enzalutamide

CAS: 915087-33-1

Enzalutamide

Formula: C₂₁H₁₆F₄N₄O₂S

Purity: 99%

Color and Shape: Solid

Molecular weight: 464.44

Ref: 54-PC109216

Enzalutamide (MDV3100)

CAS: 915087-33-1

Formula: C₂₁H₁₆F₄N₄O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 464.4360

Ref: IN-DA00GU37

Enzalutamide

CAS: 915087-33-1

Enzalutamide

Formula: C₂₁H₁₆F₄N₄O₂S

Purity: ≥98%

Molecular weight: 464.44

Ref: 54-BUP17782

Enzalutamide

CAS: 915087-33-1

Formula: C₂₁H₁₆F₄N₄O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 464.44

Ref: 4Z-E-068001

Enzalutamide

CAS: 915087-33-1

Color and Shape: Neat

Ref: 86-MM3917.00

Enzalutamide

CAS: 915087-33-1

Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP).

Formula: C₂₁H₁₆F₄N₄O₂S

Purity: 99% - 99.97%

Color and Shape: White Solid

Molecular weight: 464.44

Ref: TM-T6002

Enzalutamide

CAS: 915087-33-1

Formula: C₂₁H₁₆F₄N₄O₂S

Molecular weight: 464.44

Ref: ST-EA-CP-E16000

MDV 3100 (Enzalutamide)

Controlled Product

CAS: 915087-33-1

Applications MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);

Formula: C₂₁H₁₆F₄N₄O₂S

Color and Shape: Neat

Molecular weight: 464.44

Ref: TR-M199800

Enzalutamide

CAS: 915087-33-1

Androgen receptor antagonist

Formula: C₂₁H₁₆F₄N₄O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 464.4 g/mol

Ref: 3D-FC65076

Enzalutamide

CAS: 915087-33-1

Ref: BE-RMCE079000

4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide, Enzalutamide Impurity

CAS: 915087-33-1

Purity: 98%

Molecular weight: 464.09

Ref: 10-F575061

Enzalutamide

CAS: 915087-33-1

4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Formula: C₂₁H₁₆F₄N₄O₂S

Purity: 98%

Molecular weight: 464.44

Ref: IN-DG165432

Enzalutamide

CAS: 915087-33-1

Purity: 98%

Color and Shape: Solid

Molecular weight: 464.44

Ref: 10-F079389

4-(3-(1-(4--Cyano-3-(trifluoromethyl)phenyl)methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Controlled Product

CAS: 915087-33-1

Formula: C₃₀H₁₈F₆N₆O₂S₂

Color and Shape: Neat

Molecular weight: 672.623

Ref: TR-C999680

Enzalutamide N-2'-(Trifluoromethyl)benzonitrile

Controlled Product

CAS: 915087-33-1

Formula: C₂₈H₁₆F₇N₅O₂S

Color and Shape: Neat

Molecular weight: 619.513

Ref: TR-E559805