CAS 91524-16-2

Timolol hemihydrate

Description:

Timolol hemihydrate is a non-selective beta-adrenergic antagonist primarily used in the treatment of glaucoma and ocular hypertension. It is characterized by its ability to reduce intraocular pressure by decreasing the production of aqueous humor in the eye. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its formulation in eye drops. Timolol hemihydrate has a molecular formula that reflects its structure, containing a naphthyl moiety and an isopropanolamine group, contributing to its pharmacological activity. Its hemihydrate form indicates that it contains half a molecule of water per molecule of the drug, which can influence its stability and solubility. The compound is typically administered topically in ophthalmic solutions, and its efficacy is often evaluated through clinical studies. As with any medication, potential side effects may include ocular discomfort, systemic absorption leading to cardiovascular effects, and respiratory issues, necessitating careful monitoring in patients with pre-existing conditions.

Formula: C₁₃H₂₄N₄O₃SH₂O

InChI: InChI=1S/C13H24N4O3S.H2O/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;/h10,14,18H,4-9H2,1-3H3;1H2/t10-;/m0./s1

InChI key: InChIKey=GTPDQODZJOVTPX-PPHPATTJSA-N

SMILES: O(C[C@H](CNC(C)(C)C)O)C=1C(=NSN1)N2CCOCC2.O

Synonyms:

• 1,2,5-Thiadiazole, 2-propanol deriv.
• 2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-,hydrate (2:1), (S)-
• Betimol
• Timolol hemihydrate
• Timololhemihydrate
• 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, hydrate (2:1), (2S)-
• (-)-S-Timolol
• (-) S Timolol
• (S)-timolol hemihydrate

Timolol Hemihydrate

CAS: 91524-16-2

Color and Shape: Neat

Ref: 86-MM0440.24

Timolol hemihydrate

Controlled Product

CAS: 91524-16-2

Timolol hemihydrate is a drug that is used to treat high blood pressure and glaucoma. It is a beta-adrenergic receptor antagonist that blocks the action of these receptors, which are involved in regulating heart rate, contractility, and peripheral vascular resistance. Timolol hemihydrate has shown to be biodegradable in human serum and can be used as an implant for drug delivery. This drug also has been shown to have inhibitory effects on inflammatory bowel disease by blocking the activity of efflux proteins. Timolol hemihydrate has been shown to increase the diameter of the aortic arch by inhibiting the activity of enzymes such as elastase.

Formula: C₂₆H₅₀N₈O₇S₂

Purity: Min. 95%

Molecular weight: 650.86 g/mol

Ref: 3D-FD156839

(-)-S-Timolol

CAS: 91524-16-2

(-)-S-Timolol is an antagonist of the beta-Adrenergic .

Formula: C₁₃H₂₆N₄O₄S

Color and Shape: Solid

Molecular weight: 334.44

Ref: TM-T23573