CAS 91526-18-0

1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-

Description:

1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl- is a cyclic organic compound characterized by its dioxolane ring structure, which features two oxygen atoms and a carbonyl group. This compound is notable for its hydroxymethyl and methyl substituents, which influence its chemical reactivity and physical properties. Typically, dioxolones exhibit stability under standard conditions but can undergo hydrolysis or ring-opening reactions under acidic or basic conditions. The presence of the hydroxymethyl group can enhance solubility in polar solvents and may participate in hydrogen bonding, affecting the compound's interactions in various chemical environments. Additionally, the methyl group can influence the compound's steric properties and reactivity. This compound may find applications in organic synthesis, particularly in the development of pharmaceuticals or as intermediates in chemical reactions. As with many dioxolones, it is essential to handle this substance with care, considering potential toxicity and reactivity, especially in the presence of strong acids or bases.

Formula: C₅H₆O₄

Synonyms:

• 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
• Dmdo-Oh
• 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one(DMDO-OH)
• 4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one
• 4-Methyl-5-hydroxymethyl-2-oxo-1,3-dioxol-4-ene

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

CAS: 91526-18-0

Formula: C₅H₆O₄

Purity: 95%

Color and Shape: Liquid

Molecular weight: 130.0987

Ref: IN-DA0038JI

Azilsartan Impurity 21

CAS: 91526-18-0

Formula: C₅H₆O

Color and Shape: Brown Oil

Molecular weight: 130.10

Ref: 4Z-A-8441

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

CAS: 91526-18-0

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

Formula: C₅H₆O₄

Purity: 96%

Color and Shape: pale yellow liquid

Molecular weight: 130.10g/mol

Ref: 54-OR927927

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

Controlled Product

CAS: 91526-18-0

Formula: C₅H₆O₄

Color and Shape: Neat

Molecular weight: 130.10

Ref: TR-H939928

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

CAS: 91526-18-0

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug. The pro-drug helps to increase the bio-availability of the active drug which is generated in vivo by a base catalysed decomposition process that destroys the 1,3-dioxol-2-one ring. A high-profile example of this is the hypertension drug Alizsartan medoxomil. 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl)methyloxyoxayl chloride which provides for an alternative approach to introduce the (oxodioxolenyl)methyl carbamate group.

Formula: C₅H₆O₄

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 130.1 g/mol

Ref: 3D-FH43247

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

CAS: 91526-18-0

Formula: C₅H₆O₄

Purity: 95%

Color and Shape: Liquid

Molecular weight: 130.099

Ref: 10-F228148

Azilsartan Impurity 14

CAS: 91526-18-0

Formula: C₅H₆O₄

Molecular weight: 130.03

Ref: ST-EA-CP-A36042