Indotecan is a synthetic chemical compound classified as a topoisomerase I inhibitor, primarily investigated for its potential use in cancer therapy. It is a derivative of camptothecin, a natural alkaloid known for its anticancer properties. Indotecan exhibits a unique mechanism of action by interfering with DNA replication and transcription, leading to cell death in rapidly dividing cancer cells. The compound is characterized by its specific structural features, which enhance its solubility and bioavailability compared to other similar agents. Indotecan has shown promise in preclinical studies and clinical trials, particularly in treating various solid tumors. Its pharmacokinetic profile includes metabolism primarily through hepatic pathways, and it may have a range of side effects typical of chemotherapeutic agents, such as gastrointestinal disturbances and myelosuppression. Ongoing research aims to further elucidate its efficacy and safety profile, as well as to explore combination therapies that could enhance its therapeutic potential in oncology.

Indotecan

915303-09-2: Indotecan is a synthetic chemical compound classified as a topoisomerase I inhibitor, primarily investigated for its potential use in cancer therapy. It is a derivative of camptothecin, a natural alkaloid known for its anticancer properties. Indotecan exhibits a unique mechanism of action by interfering with DNA replication and transcription, leading to cell death in rapidly dividing cancer cells. The compound is characterized by its specific structural features, which enhance its solubility and bioavailability compared to other similar agents. Indotecan has shown promise in preclinical studies and clinical trials, particularly in treating various solid tumors. Its pharmacokinetic profile includes metabolism primarily through hepatic pathways, and it may have a range of side effects typical of chemotherapeutic agents, such as gastrointestinal disturbances and myelosuppression. Ongoing research aims to further elucidate its efficacy and safety profile, as well as to explore combination therapies that could enhance its therapeutic potential in oncology.

Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).

CAS 915303-09-2

Indotecan

Indotecan

Ref: 54-BUP01334

Indotecan

Ref: TM-T15578