CAS 915385-81-8

Opaganib

Description:

Opaganib, with the CAS number 915385-81-8, is a synthetic small molecule that functions primarily as a selective inhibitor of sphingosine kinase 2 (SK2). This inhibition is significant as it plays a role in various cellular processes, including inflammation and cancer progression. Opaganib has garnered attention for its potential therapeutic applications, particularly in treating conditions such as cancer and viral infections, including COVID-19. The compound exhibits anti-inflammatory properties and has been studied for its ability to modulate immune responses. In terms of its chemical structure, Opaganib features a unique arrangement that contributes to its biological activity, although specific structural details are proprietary. Its pharmacokinetic profile, including absorption, distribution, metabolism, and excretion, is under investigation to better understand its efficacy and safety in clinical settings. Overall, Opaganib represents a promising candidate in the realm of targeted therapies, with ongoing research aimed at elucidating its full therapeutic potential.

Formula: C₂₃H₂₅ClN₂O

InChI: InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)

InChI key: InChIKey=CAOTVXGYTWCKQE-UHFFFAOYSA-N

SMILES: C(NCC=1C=CN=CC1)(=O)C23CC4(CC(C2)CC(C4)C3)C5=CC=C(Cl)C=C5

Synonyms:

• Yeliva
• Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)-
• 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide
• Opaganib
• ABC 294640

3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide

CAS: 915385-81-8

Formula: C₂₃H₂₅ClN₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 380.9104

Ref: IN-DA00H0TB

Opaganib

CAS: 915385-81-8

Opaganib

Purity: ≥98%

Molecular weight: 380.91g/mol

Ref: 54-BUP02469

Opaganib-d4

CAS: 915385-81-8

Formula: C₂₃H₂₁D₄ClN₂O

Molecular weight: 384.94

Ref: 4Z-O-113002

Opaganib

CAS: 915385-81-8

Ref: 7W-GW1080

Opaganib

CAS: 915385-81-8

Formula: C₂₃H₂₅ClN₂O

Molecular weight: 380.92

Ref: 4Z-O-113001

Opaganib

CAS: 915385-81-8

Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).

Formula: C₂₃H₂₅ClN₂O

Purity: 98.86% - 99.85%

Color and Shape: Solid

Molecular weight: 380.91

Ref: TM-T6750

Opaganib-d15

Controlled Product

CAS: 915385-81-8

Formula: C₂₃D₁₅H₁₀ClN₂O

Color and Shape: Neat

Molecular weight: 396.003

Ref: TR-O123451

Opaganib

Controlled Product

CAS: 915385-81-8

Formula: C₂₃H₂₅ClN₂O

Color and Shape: Neat

Molecular weight: 380.91

Ref: TR-O123450

ABC 294640

CAS: 915385-81-8

ABC 294640, also known as opaganib, is a sphingosine kinase 2 (Sphk2) inhibitor with anti-inflammatory and anti-viral activity. Sphingosine kinases (SK1 and SK2) are enzymes involved not only in the sphingolipid metabolism pathway, but also in the promotion of tumour growth and pathologic inflammation. During the COVID-19 pandemic, ABC 294640 has been suggested for the treatment of critically ill patients.

Purity: Min. 95%

Ref: 3D-BA162479