CAS 915769-50-5

Dovitinib lactate

Description:

Dovitinib lactate, with the CAS number 915769-50-5, is a chemical compound that serves as a lactate salt of dovitinib, a potent inhibitor of multiple receptor tyrosine kinases, including VEGFR, PDGFR, and FGFR. This compound is primarily investigated for its potential therapeutic applications in oncology, particularly in the treatment of various cancers by inhibiting tumor growth and angiogenesis. Dovitinib lactate is characterized by its ability to interfere with signaling pathways that promote cancer cell proliferation and survival. The lactate form enhances its solubility and bioavailability, making it more suitable for pharmaceutical formulations. In terms of physical properties, it typically appears as a white to off-white solid, and its stability and solubility can vary depending on the formulation and environmental conditions. As with many pharmaceutical compounds, safety and efficacy are evaluated through clinical trials, and its use is subject to regulatory approval. Overall, dovitinib lactate represents a significant area of research in targeted cancer therapies.

Formula: C₂₁H₂₁FN₆O·C₃H₆O₃·H₂O

InChI: InChI=1/C21H21FN6O.C3H6O3.H2O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6;/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2,4H,1H3,(H,5,6);1H2

SMILES: CN1CCN(CC1)c1ccc2c(c1)[nH]c(c1c(c3c(cccc3nc1O)F)N)n2.CC(C(=O)O)O.O

Synonyms:

• 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate hydrate (1:1:1)
• 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one

4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate

CAS: 915769-50-5

Formula: C₂₄H₂₉FN₆O₅

Purity: 98%

Molecular weight: 500.5227

Ref: IN-DA006TI0

Dovitinib lactate hydrate

CAS: 915769-50-5

Dovitinib lactate hydrate

Purity: ≥98%

Molecular weight: 482.51g/mol

Ref: 54-BUP10685

Dovitinib lactate hydrate

CAS: 915769-50-5

Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).

Formula: C₂₄H₂₇FN₆O₄

Purity: 99.82%

Color and Shape: Solid

Molecular weight: 482.51

Ref: TM-T6479

Dovitinib Lactate

CAS: 915769-50-5

Receptor tyrosine kinase inhibitor; anti-angiogenesis; anti-oncogenesis

Formula: C₂₁H₂₁FN₆O·C₃H₆O₃·H₂O

Purity: Min. 95%

Color and Shape: Light (Or Pale) Yellow To Brown Solid

Molecular weight: 500.52 g/mol

Ref: 3D-FD65011