Geldanamycin, specifically the compound identified as 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy- (15R)-, is a member of the ansamycin antibiotic family, known for its potent antitumor properties. This compound exhibits a complex polycyclic structure that includes a quinone moiety, which is crucial for its biological activity. Geldanamycin functions primarily as a heat shock protein 90 (Hsp90) inhibitor, disrupting the chaperone activity of Hsp90 and leading to the degradation of client proteins involved in cancer cell proliferation and survival. Its mechanism of action makes it a subject of interest in cancer research, particularly in the development of targeted therapies. Additionally, geldanamycin derivatives are being explored for their potential in treating various malignancies, although their clinical use is limited by toxicity and solubility issues. The compound's unique structural features contribute to its biological activity, making it a valuable compound in medicinal chemistry and pharmacology.

Geldanamycin,18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-, (15R)-

91700-91-3: Geldanamycin, specifically the compound identified as 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy- (15R)-, is a member of the ansamycin antibiotic family, known for its potent antitumor properties. This compound exhibits a complex polycyclic structure that includes a quinone moiety, which is crucial for its biological activity. Geldanamycin functions primarily as a heat shock protein 90 (Hsp90) inhibitor, disrupting the chaperone activity of Hsp90 and leading to the degradation of client proteins involved in cancer cell proliferation and survival. Its mechanism of action makes it a subject of interest in cancer research, particularly in the development of targeted therapies. Additionally, geldanamycin derivatives are being explored for their potential in treating various malignancies, although their clinical use is limited by toxicity and solubility issues. The compound's unique structural features contribute to its biological activity, making it a valuable compound in medicinal chemistry and pharmacology.

TAN-420C is an antibiotic isolated from Streptomyces hygroscopicus with antitumour activity.

CAS 91700-91-3

Geldanamycin,18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-, (15R)-

TAN-420C

Ref: TM-T28920

Antibiotic TAN 420C

Ref: 7W-GA7451