CAS 91841-27-9

Lipid IVa

CAS: 91841-27-9

The outer membrane of gram-negative bacteria contains lipopolysaccharides (LPS) composed of lipid A. Lipid A is produced from the tetra-acylated precursor molecule, lipid IVA. As a part of a host's innate immune response there are toll-like receptor 4 (TLR4) and MD-2 which are expressed on immune cells. TLR4 and MD-2 recognize LPS leading to the activation of NFκB and pro-inflammatory cytokine production. Studies have suggested lipid A in Escherichia coli to be an agonist for both mouse and human TLR4, while lipid IVA can induce species specific TLR4 responses. For example for horse and mouse TLR4 and MD-2, Lipid IVA is an agonist where as it is an antagonist for TLR4 and MD-2 in humans.

Formula: C₆₈H₁₃₀N₂O₂₃P₂

Purity: Min. 95%

Molecular weight: 1,405.7 g/mol

Ref: 3D-CLP-24006-S

Lipid IVa

CAS: 91841-27-9

Lipid IVA is a tetra-acylated precursor molecule of lipid A which is a component of lipopolysaccharides (LPS) on the outer membrane of gram-negative bacteria. On the innate immune cells of hosts there are toll-like receptor 4 (TLR4) and MD-2 which recognize LPS. This recognition event ultimately leads to the activation of NFκB which in turn results in pro-inflammatory cytokine production. Studies have suggested lipid A in Escherichia coli to be an agonist for both mouse and human TLR4, while lipid IVA can induce species specific TLR4 responses. For example for horse and mouse TLR4 and MD-2, Lipid IVA is an agonist where as it is an antagonist for TLR4 and MD-2 in humans.

Formula: C₆₈H₁₃₀N₂O₂₃P₂

Purity: One Main Spot

Color and Shape: White Powder

Molecular weight: 1,405.7 g/mol

Ref: 3D-OL09566