CAS 918504-65-1

Vemurafenib

Description:

Vemurafenib is a small molecule drug primarily used in the treatment of certain types of melanoma, particularly those with the BRAF V600E mutation. It functions as a selective inhibitor of the BRAF protein, which is part of the MAPK signaling pathway that regulates cell growth and division. By inhibiting this mutated protein, vemurafenib helps to slow down or stop the proliferation of cancer cells. The compound is characterized by its relatively low molecular weight and specific structural features that enable its binding to the BRAF kinase domain. Vemurafenib is administered orally and has been associated with various side effects, including skin rash, joint pain, and fatigue. Its development marked a significant advancement in targeted cancer therapies, showcasing the importance of personalized medicine in oncology. The drug is often used in conjunction with other treatments to enhance efficacy and manage resistance. As with many targeted therapies, monitoring for adverse effects and therapeutic response is crucial during treatment.

Formula: C₂₃H₁₈ClF₂N₃O₃S

InChI: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)

InChI key: InChIKey=GPXBXXGIAQBQNI-UHFFFAOYSA-N

SMILES: C(=O)(C=1C=2C(NC1)=NC=C(C2)C3=CC=C(Cl)C=C3)C4=C(F)C(NS(CCC)(=O)=O)=CC=C4F

Synonyms:

• 1-Propanesulfonamide, N-[3-[[5-(4-Chlorophenyl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl]Carbonyl]-2,4-Difluorophenyl]-
• N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
• N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
• Plx 4032
• Plx-4032 (RG7024)
• Propane-1-sulfonic acid [3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]amide
• Rg 7204
• Ro 51-85426
• Ro 5185426
• Zelboraf
• Vemurafenib

N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide

CAS: 918504-65-1

Formula: C₂₃H₁₈ClF₂N₃O₃S

Purity: %

Color and Shape: Solid

Molecular weight: 489.9221

Ref: IN-DA00GU7A

Vemurafenib

CAS: 918504-65-1

Vemurafenib

Purity: ≥98%

Molecular weight: 489.92g/mol

Ref: 54-BUP15714

Vemurafenib

CAS: 918504-65-1

Formula: C₂₃H₁₈ClF₂N₃O₃S

Color and Shape: Off-White Solid

Molecular weight: 489.93

Ref: 4Z-V-029001

PLX4032

CAS: 918504-65-1

Ref: 7W-GW1682

Vemurafenib

CAS: 918504-65-1

Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.

Formula: C₂₃H₁₈ClF₂N₃O₃S

Purity: 98% - 99.65%

Color and Shape: Solid

Molecular weight: 489.92

Ref: TM-T2382

Vemurafenib

Controlled Product

CAS: 918504-65-1

Applications Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor
References Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);

Formula: C₂₃H₁₈ClF₂N₃O₃S

Color and Shape: Neat

Molecular weight: 489.92

Ref: TR-V118500