CAS 918639-08-4

Bosutinib monohydrate

Description:

Bosutinib monohydrate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of chronic myelogenous leukemia (CML). It selectively inhibits the BCR-ABL and SRC family kinases, which play crucial roles in the proliferation and survival of cancer cells. The monohydrate form indicates that each molecule of bosutinib is associated with one molecule of water, which can influence its solubility and stability. Bosutinib is characterized by its chemical formula, which includes a complex structure featuring a pyrimidine ring and a phenyl group, contributing to its pharmacological activity. The substance is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Common side effects may include gastrointestinal disturbances, hematological changes, and liver enzyme elevations. As with many targeted therapies, monitoring for adverse effects and drug interactions is essential during treatment. Overall, bosutinib monohydrate represents a significant advancement in the targeted therapy landscape for hematological malignancies.

Formula: C₂₆H₂₉Cl₂N₅O₃·H₂O

InChI: InChI=1S/C26H29Cl2N5O3.H2O/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27;/h11-14,16H,4-10H2,1-3H3,(H,30,31);1H2

InChI key: InChIKey=BXPOSPOKHGNMEP-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OCCCN3CCN(C)CC3)C(OC)=C2)N=CC1C#N)C4=CC(OC)=C(Cl)C=C4Cl.O

Synonyms:

• Bosutinib monohydrate
• 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-, hydrate (1:1)

Bosutinib hydrate

CAS: 918639-08-4

Bosutinib hydrate

Purity: ≥98%

Molecular weight: 548.46g/mol

Ref: 54-BUP10223

Bosutinib Monohydrate

CAS: 918639-08-4

Color and Shape: Neat

Ref: 86-MM3998.01

Bosutinib Impurity 14

CAS: 380843-75-4, 918639-08-4

Formula: C₁₀H₈Cl₂N₂O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 259.09

Ref: 4Z-B-6418

Bosutinib Monohydrate

CAS: 918639-08-4

Formula: C₂₆H₂₉Cl₂N₅O₃H₂O

Molecular weight: 530.5 : 18.0

Ref: ST-EA-CP-B80049

Bosutinib hydrate

CAS: 918639-08-4

Bosutinib hydrate (SKI-606 hydrate) is a kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of leukemia.

Formula: C₂₆H₃₁Cl₂N₅O₄

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 548.46

Ref: TM-T63875

Bosutinib monohydrate

CAS: 918639-08-4

Inhibitor of Abl and Src kinases; anti-proliferative; antineoplasticÂ

Formula: C₂₆H₂₉Cl₂N₅O₃·H₂O

Purity: Min. 95%

Color and Shape: Slightly Yellow Powder

Molecular weight: 548.46 g/mol

Ref: 3D-FB145112