CAS 91872-02-5

3,5-dichloro-1-hydroxy-pyridin-4-amine

Description:

3,5-Dichloro-1-hydroxy-pyridin-4-amine, with the CAS number 91872-02-5, is a chemical compound that belongs to the class of pyridine derivatives. It features a pyridine ring substituted with two chlorine atoms at the 3 and 5 positions, a hydroxyl group at the 1 position, and an amino group at the 4 position. This compound is typically characterized by its solid state at room temperature and may exhibit moderate solubility in polar solvents due to the presence of the hydroxyl and amino functional groups. The dichloro substitution contributes to its potential reactivity and biological activity, making it of interest in various fields, including pharmaceuticals and agrochemicals. Its molecular structure suggests potential applications in medicinal chemistry, particularly in the development of compounds with antimicrobial or herbicidal properties. Safety data should be consulted for handling and usage, as halogenated compounds can pose environmental and health risks.

Formula: C₅H₅Cl₂N₂O

InChI: InChI=1/C5H5Cl2N2O/c6-3-1-9(10)2-4(7)5(3)8/h1-2,10H,8H2

SMILES: C1=C(C(C(=CN1O)Cl)N)Cl

Synonyms:

• 4-Amino-3,5-dichloropyridine N-oxide
• 91872-02-5

Roflumilast Impurity 17

CAS: 91872-02-5

Formula: C₅H₄Cl₂N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 179.00

Ref: 4Z-R-3726

4-Amino-3,5-dichloropyridine N-Oxide

Controlled Product

CAS: 91872-02-5

Applications 4-Amino-3,5-dichloropyridine N-Oxide is the impurity of the drug Roflumilast (R639700), which is a selective phosphodiesterase 4(PDE4) inhibitor, antiasthmatic.
References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005);

Formula: C₅H₄Cl₂N₂O

Color and Shape: Neat

Molecular weight: 179.004

Ref: TR-A632005