Phenyltoloxamine, with the CAS number 92-12-6, is an antihistamine and anticholinergic agent primarily used for its sedative and anti-allergic properties. It is characterized by its ability to block histamine receptors, thereby alleviating symptoms associated with allergies, such as sneezing and itching. The compound is typically found in various formulations, including over-the-counter medications for cold and allergy relief. Phenyltoloxamine exhibits moderate lipophilicity, which allows it to cross the blood-brain barrier, contributing to its sedative effects. Its chemical structure includes a phenyl group and a toluidine moiety, which are responsible for its pharmacological activity. The substance is generally well-tolerated, but like many antihistamines, it may cause side effects such as drowsiness, dry mouth, and dizziness. Safety and efficacy profiles are well-documented, making it a common choice in symptomatic treatment. However, caution is advised when used in conjunction with other central nervous system depressants.

Phenyltoloxamine

92-12-6: Phenyltoloxamine, with the CAS number 92-12-6, is an antihistamine and anticholinergic agent primarily used for its sedative and anti-allergic properties. It is characterized by its ability to block histamine receptors, thereby alleviating symptoms associated with allergies, such as sneezing and itching. The compound is typically found in various formulations, including over-the-counter medications for cold and allergy relief. Phenyltoloxamine exhibits moderate lipophilicity, which allows it to cross the blood-brain barrier, contributing to its sedative effects. Its chemical structure includes a phenyl group and a toluidine moiety, which are responsible for its pharmacological activity. The substance is generally well-tolerated, but like many antihistamines, it may cause side effects such as drowsiness, dry mouth, and dizziness. Safety and efficacy profiles are well-documented, making it a common choice in symptomatic treatment. However, caution is advised when used in conjunction with other central nervous system depressants.

<p>Phenyltoloxamine (Bistrimin): antihistamine with sedative, analgesic properties, and Sigma-1 receptor affinity (Ki=160 nM).</p>

CAS 92-12-6

Phenyltoloxamine

Phenyltoloxamine

Ref: TM-T60391