CAS 92077-78-6

Cilazapril monohydrate

Description:

Cilazapril monohydrate is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is a white to off-white crystalline powder that is soluble in water and exhibits a molecular formula that reflects its monohydrate form. The substance works by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Cilazapril is characterized by its ability to improve cardiac function and reduce the risk of cardiovascular events. The monohydrate form indicates the presence of one molecule of water associated with each molecule of cilazapril, which can influence its stability and solubility. In terms of pharmacokinetics, cilazapril is prodrug that is converted to its active form, cilazaprilat, in the body. It is important to monitor renal function and potassium levels in patients taking this medication due to potential side effects such as hyperkalemia. Overall, cilazapril monohydrate is a valuable therapeutic agent in managing cardiovascular conditions.

Formula: C₂₂H₃₁N₃O₅·H₂O

InChI: InChI=1S/C22H31N3O5.H2O/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26;/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28);1H2/t17-,18-,19-;/m0./s1

InChI key: InChIKey=JQRZBPFGBRIWSN-YOTVLOEGSA-N

SMILES: C(O)(=O)[C@H]1N2N(CCC1)CCC[C@H](N[C@@H](CCC3=CC=CC=C3)C(OCC)=O)C2=O.O

Synonyms:

• (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate (1:1)
• 1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid 9-ethyl ester monohydrate
• 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, monohydrate, (1S-(1alpha,9alpha(R*)))-
• 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, octahydro-9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-10-oxo-, hydrate, (1S-(1-alpha,9-alpha(R*)))-
• 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, hydrate (1:1), (1S,9S)-
• 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, monohydrate, (1S,9S)-
• 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, monohydrate, [1S-[1α,9α(R*)]]-
• Cilazapril monohydrate

CILAZAPRIL CRS

CAS: 92077-78-6

CILAZAPRIL CRS

Formula: C₂₂H₃₃N₃O₆

Color and Shape: Powder

Molecular weight: 435.5139

Ref: 41-C2174000

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid,9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,monohydrate, (1S,9S)-

CAS: 92077-78-6

Formula: C₂₂H₃₃N₃O₆

Purity: %

Color and Shape: Solid

Molecular weight: 435.5139

Ref: IN-DA00GRKR

(1S,9S)-9-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate

CAS: 92077-78-6

(1S,9S)-9-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate

Purity: 98%

Molecular weight: 435.52g/mol

Ref: 54-OR1074662

Cilazapril Monohydrate

Controlled Product

CAS: 92077-78-6

Formula: C₂₂H₃₁N₃O₅·H₂O

Color and Shape: Neat

Molecular weight: 417.50

Ref: 86-MM3519.00

Cilazapril Monohydrate

CAS: 92077-78-6

Cilazapril Monohydrate (Justor) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

Formula: C₂₂H₃₁N₃O₅·H₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 435.51

Ref: TM-T6444

Cilazapril monohydrate

CAS: 92077-78-6

Cilapzapril monohydrate is the hydrated form of cilapzapril, that improves its solubility. It is a prodrug form that belongs to the group of angiotension converting enzyme inhibitors, also known as ACE inhibitors. Cilapzapril monohydrate acts as antihypertensive and inhibits the production angiotensin, a hormone that casused an increase in blood pressure due to blood vessels constriction. Cilapzapril is similar to other compounds as propranolol, atenolol, hydrochlorothiazide, captopril, enalapril, but recent studies has shown that it can also moderate the proliferative response in vessels after vascular injury.

Formula: C₂₂H₃₁N₃O₅·H₂O

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 435.51 g/mol

Ref: 3D-FC34997