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CAS 92118-27-9

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Fotemustine

Description:
Fotemustine is a synthetic alkylating agent primarily used in the treatment of certain types of cancer, particularly melanoma. It belongs to the class of nitrosoureas, which are known for their ability to cross the blood-brain barrier, making them effective against brain tumors as well. The chemical structure of Fotemustine includes a chloroethyl group that facilitates the formation of DNA cross-links, ultimately leading to cell death. It is characterized by its ability to induce apoptosis in rapidly dividing cells, which is a common mechanism of action for many chemotherapeutic agents. Fotemustine is administered intravenously and is often used in combination with other therapies to enhance its efficacy. Its pharmacokinetics involve metabolism in the liver, and it is important to monitor for potential side effects, including myelosuppression and gastrointestinal disturbances. As with many chemotherapeutic agents, careful patient selection and monitoring are crucial to optimize therapeutic outcomes while minimizing adverse effects.
Formula:C9H19ClN3O5P
InChI:InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)
InChI key:InChIKey=YAKWPXVTIGTRJH-UHFFFAOYSA-N
SMILES:P(C(NC(N(CCCl)N=O)=O)C)(OCC)(OCC)=O
Synonyms:
  • 1-(2-Chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
  • 92118-27-9
  • Diethyl (1-{[(2-Chloroethyl)(Nitroso)Carbamoyl]Amino}Ethyl)Phosphonate
  • Muphoran
  • Mustophorane
  • Phosphonic acid, [1-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-, diethyl ester
  • S 10036
  • phosphonic acid, P-[1-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-, diethyl ester
  • Fotemustine
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