CAS 92233-50-6

2'-deoxy-5-furan-2-yluridine

Description:

2'-Deoxy-5-furan-2-yluridine is a nucleoside analog characterized by its structural modification of uridine, where the ribose sugar is replaced by a 2-deoxy sugar and a furan ring is incorporated at the 5-position of the uracil base. This compound is notable for its potential applications in antiviral and anticancer therapies due to its ability to interfere with nucleic acid synthesis. The presence of the furan ring may enhance its stability and bioavailability compared to natural nucleosides. As a nucleoside, it consists of a nitrogenous base (uridine) linked to a sugar moiety (2-deoxyribose), which is essential for its biological activity. The compound's unique structure allows it to mimic natural nucleotides, potentially leading to incorporation into RNA or DNA during replication processes. Its CAS number, 92233-50-6, facilitates its identification in chemical databases and literature. Overall, 2'-deoxy-5-furan-2-yluridine represents a significant area of research in medicinal chemistry, particularly in the development of therapeutic agents targeting viral infections and cancer.

Formula: C₁₃H₁₄N₂O₆

InChI: InChI=1/C13H14N2O6/c16-6-10-8(17)4-11(21-10)15-5-7(9-2-1-3-20-9)12(18)14-13(15)19/h1-3,5,8,10-11,16-17H,4,6H2,(H,14,18,19)/t8-,10+,11+/m0/s1

Synonyms:

• 5-(Furan-2-yl)-2'-deoxyuridine
• Aids-186752
• 5-(2-Furanyl)-
• Aids186752
• Uridine, 2'-deoxy-5-(2-furanyl)-

5-(Furan-2-yl)-2'-deoxyuridine

CAS: 92233-50-6

5-(Furan-2-yl)-2'-deoxyuridine is a novel anticancer drug that is an analog of thymine. 5-(Furan-2-yl)-2'-deoxyuridine inhibits DNA synthesis by inhibiting the formation of deoxythymidylate from uracil and 5-fluorouracil, which in turn prevents the incorporation of thymine into DNA. The drug has been shown to be active against human leukemia cells in culture and to inhibit viral replication in vitro. The drug also blocks RNA synthesis by inhibiting ribonucleotide reductase, preventing the production of nucleosides from nucleotides. 5-(Furan-2-yl)-2'-deoxyuridine has been modified to improve its solubility and stability. This compound is stable for up to 3 months when stored at 4 degrees Celsius and can be used as a starting material for other chemical compounds.

Formula: C₁₃H₁₄N₂O₆

Purity: Min. 95%

Molecular weight: 294.26 g/mol

Ref: 3D-SDA23350