CAS 922491-06-3

Ipratropium bromide monohydrate

Description:

Ipratropium bromide monohydrate is a quaternary ammonium compound primarily used as a bronchodilator in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It acts as an anticholinergic agent, inhibiting the action of acetylcholine on muscarinic receptors in the airways, leading to relaxation of bronchial smooth muscle and improved airflow. The substance appears as a white to off-white crystalline powder and is hygroscopic, meaning it can absorb moisture from the environment. It is soluble in water and exhibits stability under normal storage conditions. Ipratropium bromide monohydrate is typically administered via inhalation, often in combination with other medications to enhance therapeutic effects. Its pharmacokinetics indicate a rapid onset of action, with a duration of effect that can last several hours. Safety and efficacy profiles have been well-established, making it a common choice in respiratory therapies. As with any medication, potential side effects may include dry mouth, throat irritation, and headache, necessitating careful monitoring during use.

Formula: C₂₀H₃₀NO₃·Br·H₂O

InChI: InChI=1/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19?,21+;;

InChI key: InChIKey=KEWHKYJURDBRMN-ZEODDXGYNA-M

SMILES: C(C)(C)[N@@+]1(C)[C@]2(C[C@H](OC(C(CO)C3=CC=CC=C3)=O)C[C@@]1(CC2)[H])[H].[Br-].O

Synonyms:

• 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, hydrate (1:1:1), (3-endo,8-syn)-
• 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, monohydrate, (endo,syn)-
• Ipratropium bromide monohydrate
• 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, monohydrate, (endo,syn)-(±)-
• 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, monohydrate, (3-endo,8-syn)-