CAS 92264-81-8

Hydroxybupropione

Description:

Hydroxybupropione, with the CAS number 92264-81-8, is a chemical compound that serves as a metabolite of bupropion, an antidepressant and smoking cessation aid. It is characterized by its hydroxyl group, which contributes to its solubility and reactivity. Hydroxybupropione is primarily studied for its pharmacological properties, particularly its role in the therapeutic effects of bupropion. The compound exhibits a moderate affinity for neurotransmitter receptors, influencing the levels of norepinephrine and dopamine in the brain, which can affect mood and behavior. Additionally, it is important to note that hydroxybupropione may have different pharmacokinetic and pharmacodynamic profiles compared to its parent compound, bupropion. The substance is typically analyzed in the context of drug metabolism and efficacy, as well as potential side effects. Safety and toxicity profiles are also important considerations in its study, particularly in relation to its use in clinical settings. Overall, hydroxybupropione is significant in understanding the broader effects of bupropion therapy.

Formula: C₁₃H₁₈ClNO₂

InChI: InChI=1S/C13H18ClNO2/c1-9(15-13(2,3)8-16)12(17)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3

InChI key: InChIKey=AKOAEVOSDHIVFX-UHFFFAOYSA-N

SMILES: C(C(NC(CO)(C)C)C)(=O)C1=CC(Cl)=CC=C1

Hydroxybupropion, 1mg/ml in Acetonitrile

CAS: 92264-81-8

Color and Shape: Single Solution

Ref: LP-HBP-1895-FB-1LA

Hydroxybupropion

CAS: 92264-81-8

Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).

Formula: C₁₃H₁₈ClNO₂

Purity: 99.73%

Color and Shape: Off-White Solid

Molecular weight: 255.74

Ref: TM-T11588

Hydroxybupropion

CAS: 92264-81-8

Color and Shape: Neat

Ref: LP-HBP-1895-FB-10

Hydroxybupropion

CAS: 92264-81-8

Formula: C₁₃H₁₈ClNO₂

Molecular weight: 255.75

Ref: 4Z-B-0531

Hydroxybupropion

Controlled Product

CAS: 92264-81-8

Hydroxybupropion is a drug that is used to treat depressive disorders. It acts as a nicotinic acetylcholine receptor antagonist and a dopamine uptake inhibitor, which increases the levels of dopamine in the brain. It is also an antidepressant with clinical response after oral administration. The plasma concentration-time curve of hydroxybupropion can be found by using both the conventional single-phase linear regression method and a nonlinear mixed effects model. This drug may interact with other drugs, such as antidepressants and antipsychotics, and has been shown to increase their levels in the blood stream. Hydroxybupropion also interacts with drugs that affect metabolism, such as α1-acid glycoprotein, or are taken up by the liver, such as acetylcholinesterase inhibitors. The chemical stability of hydroxybupropion can be determined by examining its stereoselectivity for acetylcholine receptors, which is dependent on pH.

Formula: C₁₃H₁₈ClNO₂

Purity: Min. 95%

Molecular weight: 255.74 g/mol

Ref: 3D-SDA26481

Hydroxybupropion

CAS: 92264-81-8

Hydroxybupropion

Formula: C₁₃H₁₈ClNO₂

Purity: By hplc: 97.8% (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 255.74g/mol

Ref: 54-BICR239