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CAS 92309-29-0

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Imipenem-cilastatin mixt.

Description:
Imipenem-cilastatin is a combination antibiotic used primarily for the treatment of serious bacterial infections. Imipenem is a broad-spectrum beta-lactam antibiotic belonging to the carbapenem class, effective against a wide range of Gram-positive and Gram-negative bacteria, including many resistant strains. Cilastatin is a renal dehydropeptidase inhibitor that prevents the degradation of imipenem in the kidneys, thereby enhancing its efficacy and reducing nephrotoxicity. The combination is particularly useful in treating infections caused by multi-drug resistant organisms. Imipenem-cilastatin is typically administered intravenously and is indicated for conditions such as pneumonia, intra-abdominal infections, and urinary tract infections. The pharmacokinetics of this mixture involve rapid distribution in body tissues, with a relatively short half-life, necessitating multiple doses for sustained therapeutic levels. Adverse effects may include gastrointestinal disturbances, allergic reactions, and, less commonly, seizures, particularly in patients with renal impairment. Overall, imipenem-cilastatin is a critical option in the antibiotic arsenal, especially for severe infections where other treatments may fail.
Formula:C28H43N5O9S2
InChI:InChI=1/C16H26N2O5S.C12H17N3O4S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/b12-6-;/t10-,11-;6-,7-,9-/m11/s1
InChI key:InChIKey=NCCJWSXETVVUHK-ZYSAIPPVSA-N
SMILES:C(N/C(=C\CCCCSC[C@@H](C(O)=O)N)/C(O)=O)(=O)[C@@H]1C(C)(C)C1.C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])(CC1SCCNC=N)[H]
Synonyms:
  • (2Z)-7-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid - (5R,6S)-3-[(2-{[(1E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (1:1)
  • (2Z)-7-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid - (5R,6S)-3-[(2-{[(E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate (1:1:1)
  • 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, [5R-[5α,6α(R*)]]-, mixt. with [R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid
  • 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, (5R,6S)-, mixt. with (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
  • 2-Heptenoic acid, 7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-, [R-[R*,S*-(Z)]]-, mixt. contg.
  • 2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, (2Z)-, mixt. contg.
  • Cilastatin-imipenem mixt.
  • Imipenem-cilastatin mixt.
  • Primaxin
  • Primaxin IV
  • See more synonyms
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Found 1 products.
  • Imipenem-cilastatin sodium hydrate, Antibiotic for Culture Media Use Only
    Biosynth
    + Info

    Imipenem-cilastatin sodium hydrate, Antibiotic for Culture Media Use Only

    CAS:
    <p>Imipenem-cilastatin sodium hydrate is a fine chemical that belongs to the category of research chemicals. It is a complex compound and versatile building block with a wide range of applications in research, development, and production of pharmaceuticals. Imipenem-cilastatin sodium hydrate has been used as a reagent for the synthesis of other compounds, as well as an intermediate for various reactions or as a scaffold for drug discovery. It is also useful in the preparation of high quality speciality chemicals.</p>
    Formula:C28H44N5NaO10S2
    Purity:40 To 60 Area-%
    Color and Shape:White Powder
    Molecular weight:697.8 g/mol

    Ref: 3D-FI148817

    1g
    928.00€
    100mg
    196.00€
    250mg
    366.00€
    500mg
    568.00€