CAS 92340-57-3

Hydroxyomeprazole

Description:

Hydroxyomeprazole, with the CAS number 92340-57-3, is a derivative of omeprazole, a well-known proton pump inhibitor (PPI) used primarily to reduce gastric acid secretion. This compound is characterized by its ability to inhibit the H+/K+ ATPase enzyme in the gastric parietal cells, thereby decreasing the production of stomach acid. Hydroxyomeprazole is typically recognized for its enhanced stability and bioavailability compared to its parent compound. It is often studied for its potential therapeutic applications in treating conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers. The chemical structure of hydroxyomeprazole includes a pyridine ring and a sulfinyl group, contributing to its pharmacological properties. Additionally, it may exhibit varying solubility and stability profiles, which can influence its efficacy and absorption in the gastrointestinal tract. As with other PPIs, the use of hydroxyomeprazole may be associated with side effects, including gastrointestinal disturbances and potential long-term risks related to nutrient absorption.

Formula: C₁₇H₁₉N₃O₄S

InChI: InChI=1S/C17H19N3O4S/c1-10-15(18-7-11(8-21)16(10)24-3)9-25(22)17-19-13-5-4-12(23-2)6-14(13)20-17/h4-7,21H,8-9H2,1-3H3,(H,19,20)

InChI key: InChIKey=CMZHQFXXAAIBKE-UHFFFAOYSA-N

SMILES: S(CC1=C(C)C(OC)=C(CO)C=N1)(=O)C=2NC=3C(N2)=CC(OC)=CC3

Synonyms:

• (4-methoxy-6-{[(6-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl}-5-methylpyridin-3-yl)methanol
• 3-Pyridinemethanol, 4-methoxy-6-[[(5-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-5-methyl-
• 3-Pyridinemethanol, 4-methoxy-6-[[(6-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-5-methyl-
• 4-Methoxy-6-[[(6-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-5-methyl-3-pyridinemethanol
• 5-Methoxy-2-[[(4-methoxy-3-methyl-5-hydroxymethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
• Hydroxyomeprazole
• [4-Methoxy-6-[(6-methoxy-1H-benzimidazol-2-yl)sulfinylmethyl]-5-methylpyridin-3-yl]methanol
• 5-Hydroxyomeprazole

5-hydroxy Omeprazole

CAS: 92340-57-3

Formula: C₁₇H₁₉N₃O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 361.4155

Ref: IN-DA00GUQL

5-hydroxy Omeprazole

CAS: 92340-57-3

5-hydroxy omeprazole, major omeprazole metabolite, formed by CYP2C19, affects gastric H+/K+ pump inhibition.

Formula: C₁₇H₁₉N₃O₄S

Color and Shape: Solid

Molecular weight: 361.42

Ref: TM-T37659

5-Hydroxy Omeprazole

CAS: 92340-57-3

Formula: C₁₇H₁₉N₃O₄S

Color and Shape: Off-White Solid

Molecular weight: 361.42

Ref: 4Z-O-026

5-Hydroxyomeprazole

CAS: 92340-57-3

5-Hydroxyomeprazole

Purity: 98%

Molecular weight: 361.42g/mol

Ref: 54-OR1075422

5-Hydroxy Omeprazole-13C-d3

CAS: 92340-57-3

Formula: C₁₆₁₃CH₁₆D₃N₃O₄S

Molecular weight: 365.43

Ref: 4Z-O-02133

5-Hydroxy Omeprazole (~5% Triethylamine as stabilizer)

CAS: 92340-57-3

Stability Hygroscopic, Temperature Sensitive
Applications 5-Hydroxy Omeprazole is the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.
References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)

Formula: C₁₇H₁₉N₃O₄S

Color and Shape: Neat

Molecular weight: 361.42

Ref: TR-H948110

5-Hydroxy Omeprazole

CAS: 92340-57-3

Formula: C₁₇H₁₉N₃O₄S

Molecular weight: 361.42

Ref: ST-EA-CP-O9064