CAS 92448-22-1: Sialyl Lewis a

Description: Sialyl Lewis A, also known as sLea, is a carbohydrate antigen that plays a significant role in cell adhesion and signaling processes, particularly in the context of cancer metastasis and inflammation. It is a glycan structure characterized by the presence of sialic acid, which contributes to its negative charge and influences its interactions with selectins, a type of cell adhesion molecule. Sialyl Lewis A is typically found on the surface of various cells, including leukocytes and tumor cells, and is involved in mediating the rolling of these cells along the endothelium during immune responses. The presence of sLea is often associated with certain types of cancers, making it a potential biomarker for diagnosis and therapeutic targeting. Its synthesis involves complex enzymatic pathways, and its expression can be regulated by various physiological and pathological conditions. Overall, Sialyl Lewis A is an important molecule in both normal physiological processes and disease states, particularly in the context of cancer biology and immunology.

Formula: C₃₁H₅₂N₂O₂₃

InChI: InChI=1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)54-25(15(42)7-36)24(12(5-34)32-10(2)38)53-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1

InChI key: InChIKey=INZOTETZQBPBCE-NYLDSJSYSA-N

SMILES: O=CC(NC(=O)C)C(OC1OC(CO)C(O)C(OC2(OC(C(O)C(O)CO)C(NC(=O)C)C(O)C2)C(=O)O)C1O)C(OC3OC(C)C(O)C(O)C3O)C(O)CO

Synonyms:

• 3′-Sialyl Lewis A
• 5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->3)-[6-deoxy-alpha-L-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy-D-glucose
• <span class="text-smallcaps">D</smallcap>-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→3)-O-[6-deoxy-α-<smallcap>L</span>-galactopyranosyl-(1→4)]-2-(acetylamino)-2-deoxy-
• O-(N-Acetyl-α-neuraminosyl)-(2→3)-O-β-<span class="text-smallcaps">D</smallcap>-galactopyranosyl-(1→3)-O-[6-deoxy-α-<smallcap>L</smallcap>-galactopyranosyl-(1→4)]-2-(acetylamino)-2-deoxy-<smallcap>D</span>-glucose
• SLe^a
• Sialyl Le^a tri
• Sialyl Lewis A tetrasaccharide
• Sialyl Lewis A, sodium salt
• Sialyl Lewis a
• D-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→3)-O-[6-deoxy-α-L-galactopyranosyl-(1→4)]-2-(acetylamino)-2-deoxy-
• Sialyl Lea tri
• O-(N-Acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→3)-O-[6-deoxy-α-L-galactopyranosyl-(1→4)]-2-(acetylamino)-2-deoxy-D-glucose

3′-Sialyl-Lewis-a tetrasaccharide

CAS: 92448-22-1

• Formula: C₃₁H₅₂N₂O₂₃
• Purity: ≥ 95%
• Color and Shape: White lyophilised solid
• Molecular weight: 820.74

3'-Sialyl Lewis A

CAS: 92448-22-1

Tetrasaccharide; tumor-associated antigen; prognostic factor

• Formula: C₃₁H₅₂N₂O₂₃
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 820.74 g/mol