CAS 924663-38-7

Rabeprazole N-oxide

Description:

Rabeprazole N-oxide is a chemical compound that serves as a metabolite of the proton pump inhibitor rabeprazole, which is commonly used to treat conditions like gastroesophageal reflux disease (GERD) and peptic ulcers. This compound is characterized by its molecular structure, which includes a pyridine ring and a sulfinyl group, contributing to its pharmacological properties. Rabeprazole N-oxide is typically a white to off-white solid and is soluble in organic solvents. Its chemical formula reflects the presence of nitrogen and oxygen atoms, indicating its role in biological systems as a metabolite. The compound exhibits properties typical of sulfoxides, including potential antioxidant activity. In terms of safety and handling, like many pharmaceuticals, it should be managed with care, adhering to standard laboratory protocols. Its pharmacokinetics and dynamics are of interest in understanding the metabolism of rabeprazole and its therapeutic effects. Overall, Rabeprazole N-oxide plays a significant role in the pharmacological profile of rabeprazole and contributes to its efficacy in treating acid-related disorders.

Formula: C₁₈H₂₁N₃O₄S

InChI: InChI=1S/C18H21N3O4S/c1-13-16(21(22)9-8-17(13)25-11-5-10-24-2)12-26(23)18-19-14-6-3-4-7-15(14)20-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,19,20)

InChI key: InChIKey=ZOEQFVVMBAVTRU-UHFFFAOYSA-N

SMILES: S(CC1=C(C)C(OCCCOC)=CC=N1=O)(=O)C=2NC=3C(N2)=CC=CC3

Synonyms:

• 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl]sulfinyl]-
• 2-[[[4-(3-Methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
• 2-(((4-(3-Methoxypropoxy)-3-methyl-1-oxopyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole
• Rabeprazole N-oxide
• 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl-1-oxide)methyl)sulphinyl)-1H-benzimidazoleRabeprazole N-oxide

Rabeprazole Related Compound B (2-{[(1H-benzo[d]imidazol-2-yl)sulfinyl]methyl}-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide)

CAS: 924663-38-7

Aromatic or modified aromatic drugs with nitrogen hetero-atom(s) only, not elsewhere specified or included

Formula: C₁₈H₂₁N₃O₄S

Color and Shape: White Powder

Molecular weight: 375.12528

Ref: 45-1598031

Rabeprazole EP Impurity D

CAS: 924663-38-7

Formula: C₁₈H₂₁N₃O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 375.44

Ref: 4Z-R-207

Rabeprazole N-Oxide

Controlled Product

CAS: 924663-38-7

Formula: C₁₈H₂₁N₃O₄S

Color and Shape: Neat

Molecular weight: 375.44

Ref: 86-MM0618.04

Rabeprazole EP Impurity D

CAS: 924663-38-7

Formula: C₁₈H₂₁N₃O₄S

Molecular weight: 375.43

Ref: ST-EA-CP-R5004

Rabeprazole N-Oxide

CAS: 924663-38-7

Impurity Rabeprazole EP Impurity D
Applications Rabeprazole N-Oxide (Rabeprazole EP Impurity D) is a Rabeprazole (R070500) impurity.
References Fellenius, E., et al.: Nature, 290, 159 (1981), Kuhler, T., et al.: J. Med. Chem., 38, 4906 (1995), Tamura, M., et al.: Chem. Pharm. Bull., 48, 1514 (2000), Miner, P., et al.: Am. J. Gastroenterology, 98, 2616 (2003),

Formula: C₁₈H₂₁N₃O₄S

Color and Shape: White To Off-White

Molecular weight: 375.44

Ref: TR-R070495