Jingzhaotoxin III is a neurotoxic peptide derived from the venom of the Chinese red-headed centipede, Scolopendra subspinipes mutilans. This toxin is characterized by its ability to selectively target voltage-gated sodium channels, leading to disruption of neuronal signaling. Jingzhaotoxin III exhibits a high affinity for specific sodium channel subtypes, which can result in paralysis and other neurotoxic effects in prey. The peptide is composed of a relatively small chain of amino acids, contributing to its stability and potency. Its structure includes disulfide bonds that are crucial for maintaining its functional conformation. Research into Jingzhaotoxin III has potential implications for the development of novel analgesics and treatments for pain management, as well as providing insights into the mechanisms of ion channel modulation. Additionally, the study of such toxins enhances our understanding of evolutionary adaptations in venomous organisms. Overall, Jingzhaotoxin III represents a significant area of interest in both toxicology and pharmacology.

Selective blocker of NaV5 channels (IC50 = 348 nM); displays no effect on other isoforms, including NaV2, NaV4, NaV6 and NaV7. Thought to inhibit sodium channel activation by binding to the NaV5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons.

Jingzhaotoxin III

925463-91-8: Jingzhaotoxin III is a neurotoxic peptide derived from the venom of the Chinese red-headed centipede, Scolopendra subspinipes mutilans. This toxin is characterized by its ability to selectively target voltage-gated sodium channels, leading to disruption of neuronal signaling. Jingzhaotoxin III exhibits a high affinity for specific sodium channel subtypes, which can result in paralysis and other neurotoxic effects in prey. The peptide is composed of a relatively small chain of amino acids, contributing to its stability and potency. Its structure includes disulfide bonds that are crucial for maintaining its functional conformation. Research into Jingzhaotoxin III has potential implications for the development of novel analgesics and treatments for pain management, as well as providing insights into the mechanisms of ion channel modulation. Additionally, the study of such toxins enhances our understanding of evolutionary adaptations in venomous organisms. Overall, Jingzhaotoxin III represents a significant area of interest in both toxicology and pharmacology.

<p>Jingzhaotoxin III is a small peptide that has been expressed in Drosophila melanogaster and has been shown to have an inhibitory effect on brain natriuretic peptide (BNP). Jingzhaotoxin III decreases the amplitude of BNP-induced camp levels, and this decrease can be reversed by removing extracellular calcium. Jingzhaotoxin III also has a voltage-gated sodium channel blocking effect, which can be inhibited by adding extracellular calcium. Jingzhaotoxin III interacts with calyces and blocks their activation. This inhibition of calyx activation is reversible when extracellular calcium is removed.</p>

CAS 925463-91-8

Jingzhaotoxin III

Jingzhaotoxin III

Ref: TM-TP2263

Jingzhaotoxin III

Ref: 3D-AMB46391