CAS 92586-35-1

3'-Azido-3'-deoxythymidine 5'-triphosphate

Description:

3'-Azido-3'-deoxythymidine 5'-triphosphate (commonly abbreviated as AZT-TP) is a nucleotide analog that plays a significant role in antiviral therapy, particularly in the treatment of HIV. It is a derivative of thymidine, where the hydroxyl group at the 3' position is replaced by an azido group, which imparts unique properties to the molecule. AZT-TP is characterized by its triphosphate structure, which is essential for its incorporation into viral DNA during replication. This incorporation leads to chain termination, effectively inhibiting viral proliferation. The compound is typically used in its triphosphate form, which is the active form that interacts with viral reverse transcriptase. AZT-TP is water-soluble and exhibits stability under physiological conditions, making it suitable for therapeutic applications. Its mechanism of action and structural modifications contribute to its effectiveness against retroviruses, although it may also exhibit cytotoxicity in host cells. Overall, AZT-TP is a crucial component in the arsenal against HIV, highlighting the importance of nucleotide analogs in antiviral drug design.

Formula: C₁₁H₁₉N₅O₁₈P₄

InChI: InChI=1/C10H16N5O13P3.CH3O5P/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20;2-1(3)7(4,5)6/h3,6-8H,2,4H2,1H3,(H,21,22)(H,23,24)(H,12,16,17)(H2,18,19,20);(H,2,3)(H2,4,5,6)/t6-,7+,8+;/m0./s1

Synonyms:

• 3-Azido-3-deoxy-thymidine-5-triphosphate
• 3'-Azido-3'-Deoxythymidine 5'-(Tetrahydrogen Triphosphate)
• Dihydroxyphosphanecarboxylic Acid Oxide - 3'-Azido-3'-Deoxythymidine 5'-(Tetrahydrogen Triphosphate) (1:1)

AZT triphosphate

CAS: 92586-35-1

AZT triphosphate is a Nucleoside Triphosphate.

Formula: C₁₀H₁₆N₅O₁₃P₃

Color and Shape: Solid

Molecular weight: 507.18

Ref: TM-TNU1229

3'-Azido-3'-deoxythymidine 5’-Triphosphate Triethylammonium Salt

Controlled Product

CAS: 92586-35-1

Stability Hygroscopic
Applications 3'-Azido-3'-deoxythymidine 5’-Triphosphate Tetraammonium Salt, is used for the preparation of drug against human retroviruses.
References Rideout, J.L., et al.: Ger. Offen., 3608606 (1986)

Formula: C₁₀H₁₆N₅O₁₃P₃(C₆H₁₅N)x

Color and Shape: Neat

Molecular weight: 507.18

Ref: TR-A825075

3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution

CAS: 92586-35-1

3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution is an inhibitor of the enzyme kinase. The active form of 3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution inhibits human immunodeficiency virus (HIV) reverse transcriptase, preventing the synthesis of viral DNA. 3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution has been shown to inhibit cancer cell growth in culture and to inhibit cancer cell proliferation in mice. This compound is also active against cancer cells that are resistant to other anti-cancer drugs. 3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution is phosphorylated by cellular kinases, which may be

Formula: C₁₀H₁₆N₅O₁₃P₃·xLi

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 507.18 g/mol

Ref: 3D-NA32049