CAS 92623-83-1
:Pravadoline
Description:
Pravadoline is a synthetic compound that belongs to the class of cannabinoids, specifically designed for potential therapeutic applications. It is known for its selective agonistic activity at cannabinoid receptors, particularly the CB1 receptor, which is primarily involved in the modulation of pain, appetite, and mood. Pravadoline has been studied for its anti-inflammatory and analgesic properties, making it a candidate for treating various conditions, including chronic pain and inflammation. The compound exhibits a relatively low toxicity profile, which is a significant consideration in pharmacological development. Its chemical structure features a bicyclic framework, contributing to its unique pharmacological properties. As with many cannabinoid derivatives, the effects of Pravadoline can vary based on dosage and individual biological factors. Research into its efficacy and safety continues, as scientists explore its potential benefits and applications in medicine. However, as with any drug, further studies are necessary to fully understand its mechanisms and therapeutic potential.
Formula:C23H26N2O3
InChI:InChI=1S/C23H26N2O3/c1-17-22(23(26)18-7-9-19(27-2)10-8-18)20-5-3-4-6-21(20)25(17)12-11-24-13-15-28-16-14-24/h3-10H,11-16H2,1-2H3
InChI key:InChIKey=MEUQWHZOUDZXHH-UHFFFAOYSA-N
SMILES:C(=O)(C=1C=2C(N(CCN3CCOCC3)C1C)=CC=CC2)C4=CC=C(OC)C=C4
Synonyms:- (4-Methoxyphenyl)(2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)methanone
- (4-Methoxyphenyl)-[2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]methanone
- (4-Methoxyphenyl)[2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]methanone
- (4-Methoxyphenyl){2-methyl-1-[2-(morpholin-4-yl)ethyl]-1H-indol-3-yl}methanone
- 92623-83-1
- Pravadolina
- Pravadolinum
- Win 48098
- methanone, (4-methoxyphenyl)[2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-
- p-Methoxyphenyl 2-Methyl-1-(2-morpholinoethyl)indol-3-yl Ketone
- Pravadoline
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 2 products.
Pravadoline
CAS:Controlled Product<p>Pravadoline is a synthetic cannabinoid from the aminoalkylindole family which acts as an agonist at the CB1 receptor (IC50= 453 nM)1. It is also a modulator of prostaglandin synthesis through the inhibition of cyclooxygenase. In vitro experiments on both human and murine breast cancer cell lines showed antiproliferative effects in conjunction with radiation2. Toxicology studies suggested nephrotoxicity in canine models3. In vitro and ex vivo assays showed inhibition of prostaglandin synthesis in mice brain, but unlike NSAIDs, did not provoke gastrointestinal lesions from in vivo oral administration. In animal studies, it showed potent analgesic effects in terms of response latency, prevention of hyperalgesia and anti-nociceptive activity against a range of mechanical, chemical and thermal stimuli1.</p>Formula:C23H26N2O3Purity:Min. 95%Color and Shape:PowderMolecular weight:378.46 g/mol
