CAS 927821-99-6

1,3-Di-HABA KanaMycin A

Description:

1,3-Di-HABA KanaMycin A, identified by its CAS number 927821-99-6, is a derivative of kanamycin, an aminoglycoside antibiotic. This compound is characterized by the presence of two 1,3-dihydroxy-2-amino-butan-1-yl (HABA) groups, which contribute to its biological activity. Like other aminoglycosides, it exhibits antibacterial properties by inhibiting protein synthesis in bacteria, making it effective against a range of Gram-negative and some Gram-positive organisms. The structural modifications in 1,3-Di-HABA KanaMycin A enhance its pharmacological profile, potentially improving its efficacy and reducing toxicity compared to its parent compound. Its solubility, stability, and interaction with bacterial ribosomes are critical factors influencing its therapeutic potential. Research into this compound may focus on its mechanism of action, resistance patterns, and possible applications in treating infections, particularly those caused by resistant bacterial strains. As with all antibiotics, careful consideration of its use is essential to mitigate the risk of developing antibiotic resistance.

Formula: C₂₆H₅₀N₆O₁₅

Synonyms:

• Amikacin Sulfate ImpurityⅡ:(Amikacin EP Impurity B)4-O-(3-amino-3-deoxy-a-D-glucopyranosyl)-6-O-(6-amino-6-deoxy-a-D-glucopyranosyl)-1,3-N-2[(2S)-4-amino-2-hydroxybutanoyl]-2-deoxy-L-streptamine
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1,N3-bis[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
• (2S,2'S)-N,N'-((1S,3R,4S,5R,6R)-4-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-5-hydroxycyclohexane-1,3-diyl)bis(4-amino-2-hydroxybutanamide)
• O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1,N3-bis[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine
• O-3-AMino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-aMino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1,N3-bis[(2S)-4-aMino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptaMine
• Amikacin Impurit Ⅱ(Impurit B)4-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-6-O-(6-amino-6-deoxy-α-D-glucopyranosyl)-1,3- N-2[(2S)-4-amino-2-hydroxy-butyryloxy]-2-deoxy-L-streptamine
• D-Streptamine,O-3-amino-3-deoxy-a-D-glucopyranosyl-(1?6)-O-[6-amino-6-deoxy-a-D-glucopyranosyl-(1?4)]-N1,N3-bis[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
• Amikacin EP Impurity B
• Amikacin Impurity 2
• AmikacinEPImpurityBFormate
• Amikacin Impurity 2（Amikacin EP Impurity B）

Amikacin EP Impurity B

CAS: 927821-99-6

Formula: C₂₆H₅₀N₆O₁₅

Color and Shape: White To Off-White Solid

Molecular weight: 686.71

Ref: 4Z-A-144002

Amikacin EP Impurity B Formate

CAS: 927821-99-6

Formula: C₂₆H₅₀N₆O₁₅·CH₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 686.71 46.03

Ref: 4Z-A-144014

1,3-Di-HABA Kanamycin A

Controlled Product

CAS: 927821-99-6

Stability Hygroscopic
Applications Amikacin (A578500) impurity B (EP).
References Naito, T., et al.: J. Antibiot., 26, 297 (1973), Weber, A., et al.: Clin. Microbiol., 21, 419 (1985), Papp, E., et al.: J. Chromatogr., 574, 93 (1992),

Formula: C₂₆H₅₀N₆O₁₅

Color and Shape: Neat

Molecular weight: 686.71

Ref: TR-D446375

1,3-Di-HABA kanamycin A

CAS: 927821-99-6

1,3-Di-HABA kanamycin A is a derivative of kanamycin A, an aminoglycoside antibiotic used to treat bacterial infections by blocking cell wall synthesis or by inhibiting protein synthesis.

Formula: C₂₆H₅₀N₆O₁₅

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 686.71 g/mol

Ref: 3D-AD21901

Amikacin EP Impurity B

CAS: 927821-99-6

Formula: C₂₆H₅₀N₆O₁₅

Molecular weight: 686.71

Ref: ST-EA-CP-A190002