CAS 92812-82-3

6-[18F]Fluoro-L-DOPA

Description:

6-[18F]Fluoro-L-DOPA, with the CAS number 92812-82-3, is a radiolabeled analog of the amino acid L-DOPA, which is primarily used in positron emission tomography (PET) imaging. This compound is characterized by the incorporation of the radioactive isotope fluorine-18, which allows for its detection in vivo. The presence of the fluorine atom enhances its metabolic stability and facilitates its uptake in dopaminergic neurons, making it particularly useful in the diagnosis and monitoring of neurological disorders, such as Parkinson's disease and certain types of brain tumors. The compound exhibits properties typical of amino acids, including solubility in water and the ability to participate in biological processes related to neurotransmitter synthesis. Its synthesis involves the nucleophilic substitution of a suitable precursor with fluorine-18, followed by purification to obtain the radiotracer in a form suitable for clinical use. Safety and handling precautions are essential due to its radioactive nature, and it is typically administered in controlled medical settings.

Formula: C₉H₁₀FNO₄

InChI: InChI=1S/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1/i10-1

InChI key: InChIKey=PAXWQORCRCBOCU-RPDRGXCHSA-N

SMILES: C([C@@H](C(O)=O)N)C1=C([18F])C=C(O)C(O)=C1

Synonyms:

• Fluorodopa (18F)
• 6-[18F]Fluoro-L-DOPA
• L-Tyrosine, 2-(fluoro-18F)-5-hydroxy-
• 2-(Fluoro-18F)-5-hydroxy-L-tyrosine
• Fluorodopa F 18