CymitQuimica logo

CAS 928326-83-4

:

Nintedanib

Description:
Nintedanib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer and pulmonary diseases. It is characterized by its ability to inhibit multiple receptor tyrosine kinases, including those involved in angiogenesis, fibrosis, and tumor growth. The chemical formula of Nintedanib is C27H29N5O3, and it features a complex structure that includes an indolinone core, which is essential for its biological activity. Nintedanib is typically administered orally and is known for its moderate to high solubility in various solvents. Its pharmacokinetics indicate a relatively long half-life, allowing for once-daily dosing in clinical settings. The substance is also associated with a range of side effects, including gastrointestinal disturbances and liver enzyme elevations, necessitating monitoring during treatment. Overall, Nintedanib represents a significant advancement in targeted therapy, particularly for conditions like idiopathic pulmonary fibrosis and non-small cell lung cancer.
Formula:C31H33N5O4
InChI:InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
InChI key:InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N
SMILES:C(\NC1=CC=C(N(C(CN2CCN(C)CC2)=O)C)C=C1)(=C\3/C=4C(NC3=O)=CC(C(OC)=O)=CC4)/C5=CC=CC=C5
Synonyms:
  • Nintedanib
  • 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
  • 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
  • BIBF 1120
  • Vargatef
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 1 products.