CAS 928659-70-5

Eliglustat tartrate

Description:

Eliglustat tartrate is a synthetic compound primarily used as a pharmacological agent in the treatment of Gaucher disease, a genetic disorder resulting from the deficiency of the enzyme glucocerebrosidase. It functions as a substrate reduction therapy, inhibiting the synthesis of glucosylceramide, thereby reducing its accumulation in cells. The substance is characterized by its molecular formula, which reflects its complex structure, and it typically appears as a white to off-white powder. Eliglustat tartrate is soluble in water and exhibits stability under standard storage conditions. Its mechanism of action involves selective inhibition of glucosylceramide synthase, which is crucial for its therapeutic efficacy. The compound is administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. As with any medication, potential side effects may include gastrointestinal disturbances and other systemic reactions, necessitating monitoring during treatment. Overall, Eliglustat tartrate represents a significant advancement in the management of Gaucher disease, providing an alternative to enzyme replacement therapy.

Formula: C₂₃H₃₆N₂O₄C₄H₆O₆

InChI: InChI=1S/C23H36N2O4.C4H6O6/c1-2-3-4-5-6-9-22(26)24-19(17-25-12-7-8-13-25)23(27)18-10-11-20-21(16-18)29-15-14-28-20;5-1(3(7)8)2(6)4(9)10/h10-11,16,19,23,27H,2-9,12-15,17H2,1H3,(H,24,26);1-2,5-6H,(H,7,8)(H,9,10)/t19-,23-;1-,2-/m11/s1

InChI key: InChIKey=VNGQLUTVKDPUJS-VUBSCCJGSA-N

SMILES: [C@@H]([C@@H](CN1CCCC1)NC(CCCCCCC)=O)(O)C=2C=C3C(=CC2)OCCO3.[C@@H]([C@H](C(O)=O)O)(C(O)=O)O

Synonyms:

• Eliglustat hemitartrate
• Octanamide, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)
• Eliglustat tartrate
• Genz 112638

Eliglustat hemitartrate

CAS: 928659-70-5

Eliglustat hemitartrate (Genz-112638) , with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.

Formula: C₂₅H₃₉N₂O₇

Purity: 99.71%

Color and Shape: Solid

Molecular weight: 479.59

Ref: TM-T11176

Eliglustat hemitartrate

CAS: 928659-70-5

Eliglustat hemitartrate

Purity: ≥98%

Molecular weight: 479.59g/mol

Ref: 54-BUP09549

Eliglustat Tartrate

CAS: 928659-70-5

Eliglustat Tartrate

Purity: 98%

Molecular weight: 959.17g/mol

Ref: 54-OR1026165

Eliglustat Tartrate

CAS: 928659-70-5

Formula: C₂₃H₃₆N₂O₄·C₄H₆O₆

Molecular weight: 404.55 150.09

Ref: 4Z-E-130001

Eliglustat hemitartrate

CAS: 928659-70-5

Eliglustat hemitartrate is a drug that inhibits the enzyme glucosylceramide synthase, which is involved in the production of glucosylceramide. Eliglustat hemitartrate is used to treat Gaucher disease, a rare genetic disorder where fatty substances accumulate in the liver and spleen. Eliglustat hemitartrate has been shown to reduce the levels of glucosylceramide in patients with Gaucher disease and may be an effective treatment for this condition. It also has been shown to inhibit P-glycoprotein (P-gp), which may allow more eliglustat to enter cells.

Formula: C₅₀H₇₈N₄O₁₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 959.17 g/mol

Ref: 3D-DMB65970

Eliglustat Tartrate

Controlled Product

CAS: 928659-70-5

Formula: (C₂₃H₃₆N₂O₄)•(C₄H₆O₆)

Color and Shape: Neat

Molecular weight: 2404.5415009

Ref: TR-E508025