CAS 929095-18-1

5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide

Description:

The chemical substance known as 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide, with the CAS number 929095-18-1, is a complex organic compound characterized by its diverse functional groups and structural features. It contains a benzimidazole moiety, which is often associated with biological activity, particularly in medicinal chemistry. The presence of a piperazine ring suggests potential interactions with biological targets, such as receptors or enzymes. Additionally, the trifluoromethyl group enhances lipophilicity and metabolic stability, which can influence the compound's pharmacokinetic properties. The thiophene ring contributes to the compound's electronic properties and may play a role in its biological activity. Overall, this compound is likely to be of interest in pharmaceutical research, particularly for its potential therapeutic applications, although specific biological activities and mechanisms would require further investigation through experimental studies.

Formula: C₂₇H₂₈F₃N₅O₂S

InChI: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1

InChI key: InChIKey=ZHJGWYRLJUCMRT-QGZVFWFLSA-N

SMILES: C(C=1C=C2N(C=NC2=CC1)C3=CC(O[C@H](C)C4=C(C(F)(F)F)C=CC=C4)=C(C(N)=O)S3)N5CCN(C)CC5

Synonyms:

• GSK 461364
• 5-[6-[(4-Methylpiperazin-1-yl)methyl]-1H-benzimidazol-1-yl]-3-[[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]oxy]thiophene-2-carboxamide
• 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide
• GSK 461364A
• 2-Thiophenecarboxamide, 5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-

GSK461364

CAS: 929095-18-1

GSK461364

Purity: 98+%

Molecular weight: 543.62g/mol

Ref: 54-PC108412

GSK461364

CAS: 929095-18-1

GSK461364

Purity: ≥98%

Molecular weight: 543.6g/mol

Ref: 54-BUP09473

GSK461364

CAS: 929095-18-1

GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.

Formula: C₂₇H₂₈F₃N₅O₂S

Purity: 99% - 99.73%

Color and Shape: Solid

Molecular weight: 543.6

Ref: TM-T6282

GSK 461364

Controlled Product

CAS: 929095-18-1

Applications GSK 461364 is a dose-dependant inhibitor of proliferating cancer cell lines as well as an apoptotic agent at higher dosage levels.
References Bogado, R. et al.: Anti-Canc. Drugs, 26, 56 (2015); Hsiao, S. et al.: J. Canc. Res. Update., 3, 108 (2014);

Formula: C₂₇H₂₈F₃N₅O₂S

Color and Shape: Neat

Molecular weight: 543.6

Ref: TR-G797705

GSK 461364

CAS: 929095-18-1

A selective ATP-competitive inhibitor of polo-like kinase 1 (Plk1). This protein is a serine/threonine kinase that regulates cell cycle progression into mitosis and is commonly overexpressed in tumors. The Plk1 inhibition resulted in 50% growth inhibition, induction of cell cycle arrest and apoptosis in neuroblastoma cell lines at concentrations < 20 nM.

Formula: C₂₇H₂₈F₃N₅O₂S

Purity: Min. 95%

Molecular weight: 543.6 g/mol

Ref: 3D-FM43315