CAS: 929095-18-1 - 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide

Formula: C₂₇H₂₈F₃N₅O₂S

InChI: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1

InChI key: InChIKey=ZHJGWYRLJUCMRT-QGZVFWFLSA-N

SMILES: O=C(N)C=1SC(=CC1OC(C=2C=CC=CC2C(F)(F)F)C)N3C=NC=4C=CC(=CC43)CN5CCN(C)CC5

Synonyms:

• GSK 461364
• 5-[6-[(4-Methylpiperazin-1-yl)methyl]-1H-benzimidazol-1-yl]-3-[[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]oxy]thiophene-2-carboxamide
• 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide
• GSK 461364A
• 2-Thiophenecarboxamide, 5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-

GSK461364

CAS: 929095-18-1

GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than …

• Formula: C₂₇H₂₈F₃N₅O₂S
• Purity: 98.85% - 99.5%
• Color and Shape: Solid
• Molecular weight: 543.6

GSK 461364

CAS: 929095-18-1

Applications GSK 461364 is a dose-dependant inhibitor of proliferating cancer cell lines as well as …

• Formula: C₂₇H₂₈F₃N₅O₂S
• Color and Shape: Neat
• Molecular weight: 543.6

GSK 461364

CAS: 929095-18-1

A selective ATP-competitive inhibitor of polo-like kinase 1 (Plk1). This protein is a serine/threonine kinase …

• Formula: C₂₇H₂₈F₃N₅O₂S
• Purity: Min. 95%
• Molecular weight: 543.6 g/mol