CAS 92999-93-4
:10-Deacetyl Baccatin
Description:
10-Deacetyl Baccatin, also known as 10-DAB, is a naturally occurring compound derived from the Pacific yew tree (Taxus brevifolia) and is a precursor in the synthesis of the anticancer drug paclitaxel (Taxol). It is classified as a diterpenoid and features a complex polycyclic structure that includes a taxane skeleton. The compound is characterized by its hydroxyl groups, which contribute to its biological activity. 10-Deacetyl Baccatin exhibits significant cytotoxic properties, making it of interest in cancer research and drug development. Its mechanism of action involves the stabilization of microtubules, thereby inhibiting cell division. The substance is typically studied in the context of its potential therapeutic applications and its role in the biosynthesis of paclitaxel. Due to its natural origin, 10-Deacetyl Baccatin is also a subject of interest in sustainable sourcing and biotechnological production methods. However, its extraction from natural sources raises concerns regarding sustainability and conservation, prompting research into synthetic and semi-synthetic alternatives.
Formula:C29H36O10
InChI:InChI=1/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5,23(34)21(33)20(14)26(29,3)4)18(32)11-19-28(22,13-37-19)39-15(2)30/h6-10,17-19,21-22,24,31-33,36H,11-13H2,1-5H3/t17-,18+,19+,21+,22+,24-,27-,28+,29+/m0/s1
Synonyms:- 10-Deacetylbaccatine III
- 10-Db Iii
- 7,11-Methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR-(2aalpha,4beta,4aalpha,6beta,9alpha,11alpha,12alpha,12aalpha,12balpha))-
- 10-Deacetylbaccatin III
- 10-DAB(10-Deacetylbaccatin Ⅲ
- 10-Dab
- 10-Dab Iii
- 10-Deacetyl Baccatin III
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